Abnormal changes in motor cortical maps in humans with spinal cord injury.
Abnormal changes in motor cortical maps in humans with spinal cord injury.
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DOI：
10.1113/jp281430
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发表时间：
2021-11
影响因子：
5.5
通讯作者：
Perez, Monica A.
中科院分区：
文献类型：
--
作者：
Tazoe, Toshiki;Perez, Monica A.
运动皮层代表重组后颈脊髓损伤（SCI）。这一重组的职能作用在很大程度上仍不得而知。使用神经导航经颅磁刺激，我们研究了慢性颈脊髓损伤患者和年龄匹配的对照组在随意收缩过程中的运动皮层地图。我们构建了运动地图在第一背侧骨间肌（FDI）在休息和自愿收缩的FDI与和不自愿收缩的肱二头肌（BB）。通过肌肉-肌腱振动检查感觉输入在这种重组中的作用。我们发现，在休息时，运动地图在SCI（22.3平方厘米）比对照组（12.6平方厘米，P < 0.001）参与者更大。运动地图面积增加自愿收缩的FDI（120.7%），并进一步增加在收缩的BB（143.9%）与休息相比，在对照组;然而，运动地图面积减少自愿收缩的FDI（69.5%），并进一步减少在收缩的BB（55.5%）与SCI的个人。在FDI的自愿收缩期间地图面积减少较大的SCI参与者是那些手部感觉缺损较大的人，并且10分钟的手部肌肉-肌腱振动增加了运动地图面积。这些结果提供了慢性SCI患者在随意收缩期间运动皮层地图异常变化的第一个证据，表明感觉输入可以帮助重塑这种重组。
Motor cortical representations reorganize following cervical spinal cord injury (SCI). The functional role of this reorganization remains largely unknown. Using neuronavigated transcranial magnetic stimulation, we examined motor cortical maps during voluntary contraction in humans with chronic cervical SCI and age-matched controls. We constructed motor maps in the first dorsal interosseous (FDI) muscle at rest and during voluntary contraction of the FDI with and without voluntary contraction of the biceps brachi (BB). The role of sensory input into this reorganization was examined by muscle-tendon vibration. We found, at rest, that motor maps were larger in SCI (22.3 cm2) compared with control (12.6 cm2, P < 0.001) participants. Motor map area increased during voluntary contraction of the FDI (120.7%) and further increased during contraction of the BB (143.9%) compared with rest in control subjects; however, motor map area decreased during voluntary contraction of the FDI (69.5%) and further decreased during contraction of the BB (55.5%) in individuals with SCI. SCI participants with larger decreases in map area during voluntary contraction of the FDI were those with larger sensory deficits in the hand and 10 minutes of hand muscle-tendon vibration increased motor map area. These results provide the first evidence of abnormal changes in motor cortical maps in humans with chronic SCI during voluntary contraction, suggesting that sensory input can help to reshape this reorganization.