The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis
The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis
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DOI：
10.1001/archneur.57.9.1289
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发表时间：
2000-09-01
影响因子：
--
通讯作者：
Becker, G
中科院分区：
文献类型：
--
作者：
Berg, D;M채urer, M;Becker, G
背景：磁共振成像。 (MRI) 数据表明，多发性硬化症 (MS) 患者的脑萎缩程度与疾病的严重程度相关。 目的：评估经颅超声 (TCS) 确定的脑室直径是否是脑萎缩的标志，并与残疾、认知能力和情绪相关。 受试者和方法：我们检查了 74 名 MS 受试者和 74 名年龄和性别匹配的 TCS 对照受试者，并评估了第三脑室和额叶的横向直径侧脑室角。使用扩展残疾状态量表对多发性硬化症受试者进行定量神经学检查。所有患有多发性硬化症的受试者均接受了 MRI、针对多发性硬化症的简短可重复神经心理测试以及针对情绪障碍的标准化测试。结果：经颅超声测量的心室直径与 MRI 测量值密切匹配（斯皮尔曼等级相关性，r = 0.7-0.9；P
Context: Magnetic resonance imaging. (MRI) data suggest that the extent of brain atrophy in patients with multiple sclerosis (MS) is related to the severity of disease.Objective: To evaluate whether ventricular diameter determined by transcranial sonography (TCS) is a marker of brain atrophy and is correlated with disability, cognitive performance, and mood.Subjects and Methods: We examined 74 subjects with MS and 74 age- and sex-matched control subjects with TCS and assessed the transverse diameter of the third ventricle and the Frontal horns of the lateral ventricles. Quantitative neurological examination was performed in subjects with MS using the Expanded Disability Status Scale. All subjects with MS underwent MRI, the Brief Repeatable Battery of Neuropsychological Tests for MS, and standardized tests For mood disorders.Results: Transcranial sonographic measurements of ventricular diameter closely matched MRI measurements (Spearman rank correlation, r = 0.7-0.9; P