PLASMINOGEN-ACTIVATOR RELEASE AT THE NEURONAL GROWTH CONE
PLASMINOGEN-ACTIVATOR RELEASE AT THE NEURONAL GROWTH CONE
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DOI：
10.1126/science.7197054
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
SEEDS, NW
中科院分区：
文献类型：
--
作者：
KRYSTOSEK, A;SEEDS, NW
用纤维蛋白覆盖试验测定了分化的神经母细胞瘤克隆细胞系[小鼠神经母细胞瘤C1300，N18，大鼠胶质瘤NG 108，杂交瘤NG 108 - 15]释放纤溶酶原激活物的位点。纤维蛋白溶酶原激活剂的释放被认为是在72%的细胞轴承神经突的生长锥。对于21%的这些细胞的生长锥是这种酶活性的主要或唯一的网站。蛋白酶在轴突尖端的选择性释放可能在体内神经元迁移和轴突生长中很重要。
The site of plasminogen activator release by differentiated neuroblastoma clonal cell lines [mouse neuroblastoma C1300, N18, rat glioma NG108, hybridoma NG108 15] was determined with a fibrin overlay assay. Release of plasminogen activator was seen at the growth cone in 72% of the cells bearing neurites. For 21% of these cells the growth cone was the predominant or exclusive site of this enzyme activity. Selective release of protease at the trailblazing tip of the neurite may be important in neuron migration and neurite growth in vivo.