Blocking IL-1 in systemic inflammation.
Blocking IL-1 in systemic inflammation.
复制标题
阻塞系统性炎症中的IL-1。
DOI：
10.1084/jem.20050640
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发表时间：
2005-05-02
影响因子：
15.3
通讯作者：
Dinarello, Charles A
中科院分区：
文献类型：
--
作者：
Dinarello, Charles A
越来越多的系统性炎性疾病的部分特征在于复发性发热、白细胞增多、贫血和急性期蛋白升高，这些疾病与白细胞介素（IL）-1活性有关，因为在特异性阻断IL-1受体后观察到快速和持续的消退。全身性发作的幼年特发性关节炎（SoJIA）也报告了全身和局部炎症的快速消退。IL-1β分泌失控可能是解释这些疾病中IL-1活性异常的常见机制。
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.