The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
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DOI：
10.1242/dev.189506
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发表时间：
2020-10-19
期刊：
影响因子：
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通讯作者：
Lewandoski M
中科院分区：
文献类型：
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作者：
Boylan M;Anderson MJ;Ornitz DM;Lewandoski M
胚胎腹面体壁的闭合是一个重要的形态发生事件，对生命至关重要。人类腹壁闭合缺陷是一类主要的出生缺陷，也是一个重大的健康负担。尽管如此，人们对腹体壁是如何形成的知之甚少。在这里，我们表明，成纤维细胞生长因子（FGF）配体FGF8，FGF17和FGF18是必不可少的这一过程。这些基因的条件突变小鼠在腹侧体壁的腹部肌肉和扩大的脐环中显示出微妙的迁移缺陷，通过该脐环，内部器官被挤出。通过细化这些基因需要使用不同的Cre线，我们表明，FGF8和FGF17需要在前体中胚层，而FGF18需要在体节。这项研究确定了复杂的和多因素的起源腹壁缺陷，并了解其起源在胚胎发育过程中具有重要意义。总结：这项研究表明，三个相关的FGF（FGF 8，FGF 17和FGF 18）合作的必要的，但研究不足，胚胎腹体壁关闭的过程中，猫。
The closure of the embryonic ventral body wall in amniotes is an important morphogenetic event and is essential for life. Defects in human ventral wall closure are a major class of birth defect and a significant health burden. Despite this, very little is understood about how the ventral body wall is formed. Here, we show that fibroblast growth factor (FGF) ligands FGF8, FGF17 and FGF18 are essential for this process. Conditional mouse mutants for these genes display subtle migratory defects in the abdominal muscles of the ventral body wall and an enlarged umbilical ring, through which the internal organs are extruded. By refining where and when these genes are required using different Cre lines, we show that Fgf8 and Fgf17 are required in the presomitic mesoderm, whereas Fgf18 is required in the somites. This study identifies complex and multifactorial origins of ventral wall defects and has important implications for understanding their origins during embryonic development. Summary: This study demonstrates that three related FGFs (FGF8, FGF17 and FGF18) cooperate in the essential, but understudied, process of embryonic ventral body wall closure in amniotes.