ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN MICE .1. ADJUVANT ACTION OF BORDETELLA-PERTUSSIS IS DUE TO VASOACTIVE AMINE SENSITIZATION AND INCREASED VASCULAR-PERMEABILITY OF THE CENTRAL NERVOUS-SYSTEM
ACUTE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN MICE .1. ADJUVANT ACTION OF BORDETELLA-PERTUSSIS IS DUE TO VASOACTIVE AMINE SENSITIZATION AND INCREASED VASCULAR-PERMEABILITY OF THE CENTRAL NERVOUS-SYSTEM
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DOI：
10.1016/0008-8749(82)90457-9
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发表时间：
1982-01-01
影响因子：
4.3
通讯作者：
BLASKETT, A
中科院分区：
文献类型：
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作者：
LINTHICUM, DS;MUNOZ, JJ;BLASKETT, A
小鼠实验性自身免疫性脑脊髓炎(EAE)依赖于百日咳杆菌混悬液作为佐剂。静脉注射。百日咳杆菌感染可增加脑组织的血管通透性，增加血管对血管活性胺的敏感性，从而促进EAE的发展。不同批次和菌株的百日咳杆菌表达EAE的效果与每种材料的血管活性胺敏化活性密切相关。Pertussigen，组胺致敏因子(HSF)，负责这些佐剂特性，而纯化的内毒素是无效的。观察西咪替丁、苯海拉明、甲基丝氨酸、利血平和赛庚啶对百日咳杆菌诱导的组胺敏感性和EAE表达的影响。赛庚啶是一种具有组胺和5-羟色胺混合阻断特性的药物，它既能阻断百日咳杆菌诱导的血管活性胺敏化，又能阻断EAE的表达。
Experimental autoimmune encephalomyelitis (EAE) in mice is dependent upon the use of B. pertussis suspensions as an adjuvant. I.v. administration of B. pertussis causes an increased vascular permeability in brain tissue and an increased vascular sensitivity to vasoactive amines which promotes the development of EAE. The efficacy of different batches and strains of B. pertussis in the expression of EAE closely correlates with the vasoactive amine sensitization activity of each material tested. Pertussigen, the histamine sensitizing factor (HSF), is responsible for these adjuvant properties whereas purified endotoxin is inactive. The effect of cimetidine, diphenhydramine, methysergide, reserpine and cyproheptadine on B. pertussis induced histamine sensitivity and the expression of EAE are examined. Cyproheptadine, an agent with mixed histamine and serotonin blocking properties, blocks both B. pertussis-induced vasoactive amine sensitization and the expression of EAE.