Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men
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DOI：
10.1016/j.atherosclerosis.2010.05.026
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发表时间：
2010-09-01
期刊：
影响因子：
5.3
通讯作者：
Miki, Tetsuro
中科院分区：
文献类型：
--
作者：
Ochi, Masayuki;Kohara, Katsuhiko;Miki, Tetsuro
目的：下肢肌肉减少症是导致肢体功能障碍、虚弱和依赖的重要原因。肌肉减少症的许多易感和潜在机制，包括年龄、久坐的生活方式、氧化应激、胰岛素抵抗和低睾酮水平，也被认为与动脉粥样硬化有关，动脉粥样硬化是老年人发病率和死亡率的另一个主要原因。在这项研究中，我们研究了我们的假设，即肌肉减少症和动脉粥样硬化相互关联，促进相互异常。方法：选取2006年3月至2007年12月在某大学医院抗衰老医生体检项目中连续招募的496名表面健康的中老年人为研究对象。采用计算机断层扫描测量大腿中部肌肉横截面积（CSA），并用体重（CSA/BW）校正。测量颈动脉内膜-中膜厚度（IMT）和臂踝脉波速度（baPWV）。结果：男性大腿肌肉CSA/BW与颈动脉IMT和baPWV呈显著负相关，而女性无显著负相关。校正其他混杂参数后，baPWV是肌减少症存在的独立危险因素（baPWV增加1 m/s的优势比=1.14,95% CI = 1.01-1.30, p < 0.05），此外还有年龄、身高、低体力活动、游离睾酮水平。相反，大腿肌肉CSA/BW是男性baPWV的独立决定因素（β =-0.15, p < 0.01），此外还有年龄、血压、甘油三酯和抗高血压药物的使用。结论：男性动脉僵硬度与大腿肌肉量有关。骨骼肌减少症和动脉粥样硬化可能有共同的途径，并相互作用，促进相互异常。2010爱思唯尔爱尔兰有限公司版权所有。
Objective: Sarcopenia of legs is an important cause of physical dysfunctions, frailty and dependence. Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which is another leading cause of morbidity and mortality in elderly subjects. In this study, we investigated our hypothesis that sarcopenia and atherosclerosis are associated with each other to facilitate mutual abnormalities.Methods: Study was performed in apparently healthy 496 middle-aged to elderly persons recruited consecutively among the visitors to the medical check-up program, Anti-Aging Doc, in a University hospital, from March 2006 to December 2007. Mid-thigh muscle cross-sectional area (CSA) was measured by computed tomography and corrected by body weight (CSA/BW). Carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) were measured.Results: Thigh muscle CSA/BW was significantly and negatively associated with carotid IMT and baPWV in men but not in women. After correction for other confounding parameters, baPWV was an independent risk for the presence of sarcopeniainmen (odds ratio of 1 m/s increase of baPWV=1.14,95% CI = 1.01-1.30, p < 0.05) in addition to age, body height, low physical activity, free testosterone level. Conversely, thigh muscle CSA/BW was an independent determinant of baPWV (beta=-0.15, p < 0.01) in addition to age, blood pressure, triglyceride, and antihypertensive drug use in men.Conclusions: Arterial stiffness is related to thigh muscle volume in men. Sarcopenia and atherosclerosis may share a common pathway and interact with each other to facilitate mutual abnormalities. (C) 2010 Elsevier Ireland Ltd. All rights reserved.