Effect of Intrahepatic Cholestasis of Pregnancy on Neonatal Birth Weight: A Meta-Analysis
Effect of Intrahepatic Cholestasis of Pregnancy on Neonatal Birth Weight: A Meta-Analysis
复制标题
妊娠期肝内胆汁淤积对新生儿出生体重影响的荟萃分析
DOI：
10.4274/jcrpe.4930
复制
发表时间：
2018-03-01
影响因子：
1.9
通讯作者：
Cong, Lin
中科院分区：
文献类型：
--
作者：
Li, Li;Chen, Yuan-Hua;Cong, Lin
目的：为评价妊娠期肝内胆汁淤积症（ICP）对新生儿出生体重的影响，检索PubMed和Web of Science数据库，检索日期为2017年4月30日。使用Mantel-Haenszel随机效应或固定效应模型，通过加权平均差（WMD）和95%置信区间（CI）总结结局。潜在的发表偏倚进行了测试，使用漏斗图和Egger的回归和Begg的test.Results的方法：共8个研究被纳入我们的荟萃分析。6项研究报告了ICP和对照妊娠的新生儿出生体重数据。6项研究的汇总数据显示，ICP组的出生体重明显轻于对照组。总体合并WMD为-175 g（95% CI：-301，-48）。晚发型ICP组新生儿出生体重明显高于早发型ICP组（WMD：267 g，95% CI：168，366）。此外，早发性ICP与晚发性ICP相比，出生体重较低。
Objective: To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) on neonatal birth weight.Methods: Potential articles were identified by searching PubMed and Web of Science databases on April 30th, 2017. Using the Mantel-Haenszel random-effects or fixed-effects model, outcomes were summarized through weighted mean difference (WMD) and 95% confidence intervals (CI). Potential publication bias was tested using a funnel plot and the methods of Egger's regression and Begg's test.Results: A total of eight studies were included in our meta-analysis. Six studies reported data on neonatal birth weight in ICP and control pregnancies. Pooled data from the six studies showed that the birth weight in the ICP group was significantly lighter than in the control group. The overall pooled WMD was -175 g (95% CI: -301, -48). Meanwhile, pooled data from the other two studies indicated that the birth weight in the late-onset ICP group was heavier than in the early-onset ICP group (WMD: 267 g, 95% CI: 168, 366).Conclusion: Neonatal birth weights in ICP pregnancies were lower than in normal pregnancies. Furthermore, early-onset ICP is associated with a lower birth weight than late-onset ICP.