Association of an Overhydrated State With the Liver Fibrosis and Prognosis of Cirrhotic Patients
Association of an Overhydrated State With the Liver Fibrosis and Prognosis of Cirrhotic Patients
复制标题
DOI：
10.21873/invivo.11912
复制
发表时间：
2020-05-01
期刊：
影响因子：
2.3
通讯作者：
Nishiguchi, Shuhei
中科院分区：
文献类型：
--
作者：
Kishino, Kyohei;Enomoto, Hirayuki;Nishiguchi, Shuhei
背景/目的：生物阻抗分析（BIA）可以通过细胞外水/全身水（ECW/TBW）值指示过度水合状态。本研究旨在评估该值在慢性肝病（CLD）患者中的临床意义。患者和方法：共有552名CLD患者接受了肝活检，并进行了人体测量评估和基于BIA的身体成分分析。评估ECW/TBW值与肝纤维化和营养状况的关系。还评估了ECW/TBW值与肝硬化患者（N=209）预后之间的关系。结果：ECW/TBW值随着肝纤维化进展而增加，并且也与肌肉质量减少/肌肉减少有关。水化过度的存在与糖尿病患者预后不良有关。结论：ECW/TBW值的增加与肝纤维化进展和营养不良有关，并与肝硬化患者的预后有关。
Background/Aim: A bioimpedance analysis (BIA) can indicate an overhydrated state as the extracellular water/total body water (ECW/TBW) value. This study aimed to assess the clinical significance of this value in patients with chronic liver diseases (CLDs). Patients and Methods: A total of 552 CLD patients who received a liver biopsy and underwent anthropometric assessment and BIA-based body composition analysis were enrolled. The association of the ECW/TBW value with the liver fibrosis and nutritional status was assessed. The relationship between the ECW/TBW value and the prognosis of cirrhotic patients (N=209) was also evaluated. Results: The ECW/TBW value increased as liver fibrosis progressed and was also related to decreased muscle mass/sarcopenia. The presence of overhydration was associated with a poor prognosis of cirrhotic patients. Conclusion: An increased ECW/TBW value was associated with progressive liver fibrosis and malnutrition and related to the prognosis of cirrhotic patients.