Asymmetric, Catalytic, and Direct Self-Aldol Reaction of Acetaldehyde Catalyzed by Diarylprolinol
Asymmetric, Catalytic, and Direct Self-Aldol Reaction of Acetaldehyde Catalyzed by Diarylprolinol
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DOI：
10.1021/ol802438u
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发表时间：
2008-12-18
期刊：
影响因子：
5.2
通讯作者：
Ishikawa, Hayato
中科院分区：
文献类型：
--
作者：
Hayashi, Yujiro;Samanta, Sampak;Ishikawa, Hayato
在NMP中，二芳基脯氨酸醇催化了乙醛的不对称、催化和直接的自醛反应，得到了由自醛产物与另一个乙醛分子反应生成的三聚缩醛，该反应产率中等，对映选择性好。缩醛是自醛产物的合成等价物，它可以在一个锅中转化为其他合成有用的化合物而不影响对映选择性。
An asymmetric, catalytic, and direct self-aldol reaction of acetaldehyde was catalyzed by diarylprolinol in NMP, affording the trimer acetal, which was generated by the reaction of the self-aldol product with another acetaldehyde molecule in a moderate yield with good enantioselectivity. Acetal is the synthetic equivalent of the self-aldol product, which can be converted into other synthetically useful compounds in one pot without compromising the enantioselectivity.