Elevated trace element concentrations in malignant breast tissues
Elevated trace element concentrations in malignant breast tissues
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DOI：
10.1259/bjr.70.832.9166074
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发表时间：
1997-04-01
影响因子：
2.6
通讯作者：
Looi, LM
中科院分区：
文献类型：
--
作者：
Ng, KH;Bradley, DA;Looi, LM
对46例女性乳腺肿瘤的癌组织和癌旁正常组织进行了体外中子活化分析（NAA）。目的是调查微钙化发展的组织的化学环境，并开发一种区分恶性和正常乳腺组织的方法。Al、Br、Ca、Cl、Co、Cs、Fe、K、Mn、Na、Rb和Zn元素在癌组织中显著较高（所有p < 0.001;除Co外，p < 0.003，Wilcoxon符号秩检验）。此外，一个显着的相关性（0.80，斯皮尔曼等级相关）被发现Rb和Zn在肿瘤组织中。目前的结果得到了其他人的研究结果的支持。乳腺癌组织中这些元素浓度升高的相关性仍然是一个推测的问题。有证据表明，在恶性乳腺组织中，细胞活性和血液供应增加以及微钙化的形成都与此有关。这项研究表明，乳腺组织的元素组成和乳腺颗粒的形成之间的关联。也就是说，元素浓度的升高和乳腺中的聚集性钙化可能相关。
In vitro neutron activation analysis (NAA) was performed on malignant and adjacent normal tissue from 46 human female breast tumours. The objective was to investigate the chemical environment of the tissues within which microcalcifications develop and to develop a method for discrimination between malignant and normal breast tissue. The elements Al, Br, Ca, Cl, Co, Cs, Fe, K, Mn, Na, Rb and Zn were significantly higher in the cancer tissues (all p < 0.001; except for Co, p < 0.003, Wilcoxon signed-ranks test). In addition, a significant correlation (0.80, Spearman rank correlation) was found for Rb and Zn in tumour tissues. Present results are supported by the findings of others. The relevance of elevated concentrations of these elements in cancer breast tissue remains a matter of conjecture. Evidence suggests that there is a connection both with increased cellular activity and blood supply and the formation of microcalcifications in malignant breast tissues. This study suggests an association between the elemental composition of breast tissues and the formation of breast particles. That is, elevations of elemental concentration and clustered calcifications in breast are possibly related.