Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
Simultaneous trapping and imaging of microbubbles at clinically relevant flow rates
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DOI：
10.1109/ultsym.2016.7728393
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发表时间：
2016-09
期刊：
影响因子：
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通讯作者：
S. Harput;Luzhen Nie;D. Cowell;T. Carpenter;B. Raiton;J. Mclaughlan;S. Freear
中科院分区：
文献类型：
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作者：
S. Harput;Luzhen Nie;D. Cowell;T. Carpenter;B. Raiton;J. Mclaughlan;S. Freear
使用微泡和超声的非侵入性靶向药物递送机制吸引了越来越多的兴趣。微泡可以装载治疗有效载荷，并通过超声成像进行跟踪，以在超声靶向位置选择性地释放其有效载荷。在这项研究中，提出了一种超声捕获的方法，同时成像和控制的微气泡在流动中的位置，通过使用声辐射力。预期靶向药物递送方法将受益于超声捕集器的使用，因为捕集将增加人体中所需位置处的MB浓度。通过使用超声研究系统UARP II和线阵换能器产生超声陷阱。阱被设计成不对称的，以在阱的入口处产生较弱的辐射力，以进一步促进微泡进入。生成可以在长持续时间捕获波形和短持续时间成像波形之间切换的脉冲序列。选择高帧率平面波成像用于在1 kHz下监测捕获的微泡。通过在直径为3.5 mm的血管中注入以80 mL/min流速流动的SonoVue微泡，在超声体模中解释和演示了超声陷阱的工作原理。
Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their payload at ultrasound-targeted locations. In this study, an ultrasonic trapping method is proposed for simultaneously imaging and controlling the location of microbubbles in flow by using acoustic radiation force. Targeted drug delivery methods are expected to benefit from the use of the ultrasonic trap, since trapping will increase the MB concentration at a desired location in human body. The ultrasonic trap was generated by using an ultrasound research system UARP II and a linear array transducer. The trap was designed asymmetrically to produces a weaker radiation force at the inlet of the trap to further facilitate microbubble entrance. A pulse sequence was generated that can switch between a long duration trapping waveform and short duration imaging waveform. High frame rate plane wave imaging was chosen for monitoring trapped microbubbles at 1 kHz. The working principle of the ultrasonic trap was explained and demonstrated in an ultrasound phantom by injecting SonoVue microbubbles flowing at 80 mL/min flow rate in a 3.5 mm diameter vessel.