Automated detection of pathologic white matter alterations in Alzheimer's disease using combined diffusivity and kurtosis method
Automated detection of pathologic white matter alterations in Alzheimer's disease using combined diffusivity and kurtosis method
复制标题
使用扩散率和峰度组合方法自动检测阿尔茨海默病的病理性白质改变
DOI：
10.1016/j.pscychresns.2017.04.004
复制
发表时间：
2017-06-30
影响因子：
2.3
通讯作者：
Ming, Dong
中科院分区：
文献类型：
--
作者：
Chen, Yuanyuan;Sha, Miao;Ming, Dong
扩散张量成像（DTI）和扩散峰度成像（DKI）是检测阿尔茨海默病等疾病微结构异常的重要扩散MRI技术。DKI相对于DTI的优势已被广泛报道;然而，在临床环境中，扩散率和峰度之间的模糊关系尚未明确显示。在这项研究中，我们假设DKI中的扩散率和峰度的组合与单独的扩散率或峰度相比提高了DKI检测阿尔茨海默病的能力。具体而言，基于支持向量机的方法被应用到联合收割机的扩散率和峰度，并比较不同的指标数据集。进行了严格的评估，以确保所有分类器的可靠性。然后，使用来自优化的分类器的数据来检测异常。在53名受试者中，包括27名阿尔茨海默病患者，使用该组合获得了96.23%的高准确性性能。与单独使用相比，联合使用选择了评分更高的异常区域。结果表明，更精确的扩散系数和互补峰度主要有助于在DKI的组合的高性能。这项研究提供了进一步了解DKI和扩散率和峰度之间的关系，在阿尔茨海默病的病理白色物质的改变。
Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) are important diffusion MRI techniques for detecting microstructure abnormities in diseases such as Alzheimer's. The advantages of DKI over DTI have been reported generally; however, the indistinct relationship between diffusivity and kurtosis has not been clearly revealed in clinical settings. In this study, we hypothesize that the combination of diffusivity and kurtosis in DKI improves the capacity of DKI to detect Alzheimer's disease compared with diffusivity or kurtosis alone. Specifically, a support vector machine-based approach was applied to combine diffusivity and kurtosis and to compare different indices datasets. Strict assessments were conducted to ensure the reliability of all classifiers. Then, data from the optimized classifiers were used to detect abnormalities. With the combination, high accuracy performances of 96.23% were obtained in 53 subjects, including 27 Alzheimer's patients. More highly scored abnormal regions were selected by the combination than alone. The results revealed that more precise diffusivity and complementary kurtosis mainly contributed to the high performance of the combination in DKI. This study provides further understanding of DKI and the relationship between diffusivity and kurtosis in pathologic white matter alterations in Alzheimer's disease.