The development of a Ki-1-positive large cell non-Hodgkin's lymphoma in pagetoid reticulosis.
The development of a Ki-1-positive large cell non-Hodgkin's lymphoma in pagetoid reticulosis.
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佩吉样网状组织增生症中 Ki-1 阳性大细胞非霍奇金淋巴瘤的发展。
DOI：
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发表时间：
1989
影响因子：
3.6
通讯作者：
Wantzin Gl
中科院分区：
文献类型：
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作者：
E. Ralfkiaer;K. Thomsen;N. Agdal;Hou;Wantzin Gl
本文报告一例弥散性变异型页样网状病，在患病多年后发展为t细胞型大细胞间变性（Ki-1）淋巴瘤。免疫表型检查和单细胞DNA测定显示淋巴瘤细胞DNA异常，增殖率高。细胞活化相关抗原呈阳性，表达t辅助/诱导表型。类似的表型表达的肿瘤细胞共存病变的网页样网状病。这些发现支持了这样一种观点，即页状网状病是皮肤t细胞淋巴瘤的一种变体，起源于活化的淋巴样细胞，有时可能发展为潜在的更具侵袭性的淋巴样恶性肿瘤。
A case of the disseminated variant of pagetoid reticulosis is described which progressed after many years of disease to a large cell anaplastic (Ki-1) lymphoma of T-cell type. The lymphoma cells showed abnormal cellular DNA and a high proliferative rate, as revealed by immunophenotypic examination and single-cell DNA measurements. The cells were positive for activation associated antigens and expressed a T-helper/inducer phenotype. A similar phenotype was expressed by the neoplastic cells in the co-existing lesions of pagetoid reticulosis. These findings support the view that pagetoid reticulosis is a variant of the cutaneous T-cell lymphomas which originates from activated lymphoid cells and which may on occasion progress to a potentionally more aggressive lymphoid malignancy.