From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.
From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.
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DOI：
10.1177/1947601911407327
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发表时间：
2010-12-01
期刊：
影响因子：
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通讯作者：
Daley, George Q
中科院分区：
文献类型：
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作者：
Kharas, Michael G;Daley, George Q
Src 癌基因的发现是改善癌症化疗的漫长旅程的第一步。在这篇综述中，我们探讨了 Src 和 BCR-ABL、信号转导以及癌基因成瘾的最新进展，并庆祝 Hidesaboro Hanafusa 和许多研究人员开创了针对酪氨酸激酶癌蛋白的靶向治疗时代。
The discovery of the Src oncogene was the first step on a long journey toward improved cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and recent advances in oncogene addiction and celebrate Hidesaboro Hanafusa and the many researchers who ushered in the age of target-directed therapy against tyrosine kinase oncoproteins.