A comparison of gag-pol precursor cleavage in naturally arising HIV variants.
A comparison of gag-pol precursor cleavage in naturally arising HIV variants.
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自然产生的 HIV 变体中 gag-pol 前体裂解的比较。
DOI：
10.1007/978-1-4615-5373-1_7
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发表时间：
1998
影响因子：
--
通讯作者：
Dunn,BM
中科院分区：
文献类型：
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作者：
Bloom,G;Perez,E;Parikh,S;Kay,J;Mills,J;Goodenow,M;Dunn,BM
目前，三种HIV- i蛋白酶抑制剂在临床治疗HIV感染方面显示出前景。然而，耐药性的发展仍然是蛋白酶抑制剂治疗中的一个重要考虑因素。在接受抑制剂治疗和未接受抑制剂治疗的个体中都观察到导致耐药性的蛋白酶突变（Borman et al., 1996; Condra et al., 1995）。在包括p7和裂解位点序列在内的聚合区也观察到更高程度的变异（Barrie et al., 1996）。
Currently, three inhibitors of HIV-I protease are showing promise in clinical use against HIV infection. However, the development of resistance continues to be an important consideration in protease inhibitor therapy. Mutations in protease which lead to resistance have been observed in both inhibitor treated and untreated individuals (Borman et al., 1996; Condra et al., 1995). Variations have also been observed to a higher degree in areas of thegagregion including p7, and the cleavage site sequences (Barrie et al., 1996).