Omega-3 fatty acid rich diet prevents diabetic renal disease
Omega-3 fatty acid rich diet prevents diabetic renal disease
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DOI：
10.1152/ajprenal.90326.2008
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发表时间：
2009-02-01
影响因子：
4.2
通讯作者：
Maric, Christine
中科院分区：
文献类型：
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作者：
Garman, Joseph H.;Mulroney, Susan;Maric, Christine
Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric C.富含Omega-3脂肪酸饮食对糖尿病肾病的预防作用。[J] .中国生物医学工程学报，2009,31(6):559 - 563。首次发表于2008年12月3日；doi: 10.1152 / ajprenal.90326.2008。-Omega-3多不饱和脂肪酸（n-3 PUFA）对心血管疾病、IgA和糖尿病肾病有有益作用；然而，这些益处背后的机制尚不清楚。该研究将雄性sd - dawley大鼠随机分为四组：非糖尿病（ND）、链脲佐菌素诱导的糖尿病(D)、糖尿病和高n-3 PUFA饮食（D+菜籽油），以及糖尿病和高n-6 (omega-6) PUFA饮食（D+玉米）。研究治疗进行了30周。D+菜籽油显著降低糖尿病相关尿白蛋白排泄增加（ND 17.8 + 6.4; D 97.3 +/- 9.4； D+菜籽油8.3 +/- 2.2 mg/天）；收缩压（ND 153 +/- 9; D 198 +/- 7； D+菜籽油162 +/- 9 mmHg）；肾小球硬化（ND 0.6 +/- 0.2; D 1.8 +/- 0.2； D+菜籽油0.8 +/- 0.1 AU）；肾皮质小管间质纤维化（ND 1.2 +/- 0.2; D 2.0 +/- 0.2； D+菜籽油1.1 +/- 0.1）和外髓质内条纹（ND 1.0 +/- 0.2; D 2.1 +/- 0.2； D+菜籽油1.1 +/- 0.2 AU）。D+玉米也有肾保护作用，但程度不及D+菜籽油（尿白蛋白排泄，33.8 +/- 6.1 mg/天；收缩压，D+玉米177 +/- 6 mmHg；肾小球硬化，D+ /-玉米1.2 +/- 0.3 AU；皮质小管间质纤维化，D+玉米1.6 +/- 0.1 AU；髓管间质纤维化，D+玉米1.5 +/- 0.1 AU）。此外，D+菜籽油降低了D相关的I型和IV型胶原蛋白、IL-6、MCP-1、转化生长因子β和CD68表达的增加。这些观察结果表明，高饮食摄入n-3 PUFA在减少糖尿病肾病方面具有有益作用。
Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric C. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am J Physiol Renal Physiol 296: F306-F316, 2009. First published December 3, 2008; doi:10.1152/ajprenal.90326.2008.-Omega-3 poly-unsaturated fatty acids (n-3 PUFA) show beneficial effects in cardiovascular disease, IgA, and diabetic nephropathy; however, the mechanisms underlying these benefits are unknown. The study was performed in male Sprague-Dawley rats randomly divided into four treatment groups: nondiabetic (ND), streptozotocin-induced diabetic (D), diabetic and fed a high n-3 PUFA diet (D+canola), and diabetic and fed a high n-6 (omega-6) PUFA diet (D+corn). Study treatments were carried out for 30 wk. D+canola significantly decreased diabetes-associated increases in urine albumin excretion (ND 17.8 + 6.4; D 97.3 +/- 9.4; D+canola 8.3 +/- 2.2 mg/day); systolic blood pressure (ND 153 +/- 9; D 198 +/- 7; D+canola 162 +/- 9 mmHg); glomerulosclerosis (ND 0.6 +/- 0.2; D 1.8 +/- 0.2; D+canola 0.8 +/- 0.1 AU); and tubulointerstitial fibrosis in the renal cortex (ND 1.2 +/- 0.2; D 2.0 +/- 0.2; D+canola 1.1 +/- 0.1) and the inner stripe of the outer medulla (ND 1.0 +/- 0.2; D 2.1 +/- 0.2; D+canola 1.1 +/- 0.2 AU). D+corn also exerted renoprotection, but not to the same degree as D+canola (urine albumin excretion, 33.8 +/- 6.1 mg/day; systolic blood pressure, D+corn 177 +/- 6 mmHg; glomerulosclerosis, D +/- corn 1.2 +/- 0.3 AU; cortical tubulointerstitial fibrosis, D+corn 1.6 +/- 0.1 AU; medullary tubulointerstitial fibrosis, D+corn 1.5 +/- 0.1 AU). In addition, D+canola attenuated D-associated increase in collagen type I and type IV, IL-6, MCP-1, transforming growth factor-beta, and CD68 expression. These observations indicate a beneficial effect of high dietary intake of n-3 PUFA in reducing diabetic renal disease.