Killing of target cells by lymphocytes: a mechanistic view.
Killing of target cells by lymphocytes: a mechanistic view.
复制标题
淋巴细胞杀死靶细胞：机制观点。
DOI：
10.1152/physrev.1989.69.1.250
复制
发表时间：
1989
影响因子：
33.6
通讯作者：
Young,JD
中科院分区：
文献类型：
--
作者：
Young,JD
免疫系统的一项主要任务是保护身体免受转化细胞、受病毒感染的细胞和其他外来入侵者的侵袭，包括细菌和其他微生物。在执行这一功能的细胞类型中，淋巴细胞可以被视为免疫系统的步兵，因为它们直接对入侵的细胞进行致命的打击。杀死靶细胞(TC)并不是哺乳动物系统独有的，因为许多低等生物，包括酵母、真菌、原生动物和细菌，也能够损伤其他类型的细胞。然而，淋巴细胞介导的杀伤不同于其他形式的细胞毒作用，因为需要淋巴细胞和TC之间的密切接触才能引发杀伤事件。一个
A major task of the immune system is to defend the body against transformed cells, cells infected by viruses, and other foreign invaders, including bacteria and other microorganisms. Among the cell types assigned to carry out this function are lymphocytes, which can be viewed as the foot soldiers of the immune system in that they deliver directly lethal hits against intruding cells. Killing of target cells (TCs) is not unique to mammalian systems, as a number of lower organisms, including yeast, fungi, protozoa, and bacteria, are also capable of injuring other cell types. However, the killing mediated by lymphocytes differs from other forms of cytotoxicity in that a close contact between the lymphocyte and the TC is required to elicit the killing event. A