PD 165929 - The first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist
PD 165929 - The first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist
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DOI：
10.1016/0960-894x(96)00481-7
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发表时间：
1996-11-05
影响因子：
2.7
通讯作者：
Williams, SC
中科院分区：
文献类型：
--
作者：
Eden, JM;Hall, MD;Williams, SC
In this paper we describe the development of a novel series of non-peptide neuromedin-B (NMB) receptor ligands as exemplified by PD 165929. PD 165929, which exhibits nanomolar affinity for the NMB receptor (Ki=6.3nM), has been demonstrated to be a competitive antagonist at this receptor (appK(B)=7.6nM) and is selective over the corresponding gastrin-releasing peptide (GRP) receptor type (Ki>10000nM). Copyright (C) 1996 Elsevier Science Ltd
