Reduced Foxp3 protein expression is associated with inflammatory disease during human T lymphotropic virus type 1 infection
Reduced Foxp3 protein expression is associated with inflammatory disease during human T lymphotropic virus type 1 infection
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DOI：
10.1086/503874
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发表时间：
2006-06-01
影响因子：
6.4
通讯作者：
Jacobson, S
中科院分区：
文献类型：
--
作者：
Oh, U;Grant, C;Jacobson, S
Foxp 3蛋白是CD 4（+）CD 25（+）调节性T（T-reg）细胞的特异性标志物，其表达对其发育和功能至关重要。一些研究已经证明了Foxp 3表达在人类炎症性疾病期间的失调。人类嗜T淋巴细胞病毒1型（HTLV-1）的感染与许多炎症性疾病的发展有关，包括脊髓病，尽管大多数感染HTLV-1的个体仍然无症状。为了研究在HTLV-1感染过程中T-reg细胞在炎症性疾病发展中所起的作用，我们通过流式细胞术检测了Foxp 3的表达。我们的分析表明，HTLV-1相关性脊髓病/热带痉挛性下肢轻瘫与外周血白细胞中Foxp 3的表达降低（与无症状HTLV-1携带者和健康供体相比）相关。在HTLV-1感染的个体中，Foxp 3表达与HTLV-1 tax前病毒DNA载量呈负相关。这些结果表明，受损的Foxp 3表达可能有助于在HTLV-1感染期间炎症性疾病的发展。
The Foxp3 protein is a specific marker of CD4(+)CD25(+) regulatory T (T-reg) cells, and its expression is critical to their development and function. Several studies have demonstrated the dysregulation of Foxp3 expression during human inflammatory diseases. Infection with human T lymphotropic virus type 1 (HTLV-1) is associated with the development of a number of inflammatory conditions, including myelopathy, although the majority of individuals who are infected with HTLV-1 remain asymptomatic. To examine the role played by T-reg cells in the development of inflammatory disease during HTLV-1 infection, we examined Foxp3 expression by flow cytometry. Our analysis showed that HTLV-1-associated myelopathy/tropical spastic paraparesis was associated with a lower expression ( compared with that in asymptomatic HTLV-1 carriers and healthy donors) of Foxp3 in peripheral-blood leukocytes. In individuals infected with HTLV-1, Foxp3 expression was inversely correlated with HTLV-1 tax proviral DNA load. These results suggest that impaired Foxp3 expression may contribute to the development of inflammatory disease during HTLV-1 infection.