AGE-RELATED DECLINE IN RESISTANCE OF MICE TO INFECTION WITH INTRACELLULAR PATHOGENS
AGE-RELATED DECLINE IN RESISTANCE OF MICE TO INFECTION WITH INTRACELLULAR PATHOGENS
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DOI：
10.1128/iai.16.2.593-598.1977
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
REMINGTON, JS
中科院分区：
文献类型：
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作者：
GARDNER, ID;REMINGTON, JS
BALB/c雌性小鼠对弓形虫和单核细胞增生李斯特菌感染的抵抗力随年龄增长而下降。早在9个月时下降明显。随着年龄的增长，动物的年龄进一步增加。这种与年龄相关的抵抗力下降并不局限于BALB/c雌性小鼠; C57 BL/6品系的雄性和雌性小鼠表现出相似的反应。对于这两种病原体，老年小鼠对毒性较小的菌株表现出更明显的易感性。老年小鼠正常血清在感染T.弓形虫导致对该生物体的易感性增加，这表明存在抑制因子或缺乏存在于幼鼠血清中的增强因子。
Resistance to infection with Toxoplasma gondii and Listeria monocytogenes in BALB/c female mice decreased with increasing age. The decrease was apparent as early as 9 mo. of age and was more marked as the animals aged further. This age-related decline in resistance was not restricted to BALB/c female mice; male and female mice of the C57BL/6 strain exhibited similar responses. With both pathogens, aged mice showed a more marked susceptibility to the strain of lesser virulence. Transfer of normal serum from old mice to young or old mice before infection with T. gondii resulted in an increased susceptibility to this organism, suggesting the presence of inhibitory factors or the absence of potentiating factors that are present in the serum of young mice.