Carriage of multidrug-resistant Streptococcus pneumoniae and impact of chemoprophylaxis during an outbreak of meningitis at a day care center
Carriage of multidrug-resistant Streptococcus pneumoniae and impact of chemoprophylaxis during an outbreak of meningitis at a day care center
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DOI：
10.1086/313451
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发表时间：
1999-11-01
影响因子：
11.8
通讯作者：
Butler, JC
中科院分区：
文献类型：
--
作者：
Craig, AS;Erwin, PC;Butler, JC
某日托中心（DCC） 5天内发生3例多药耐药血清型14型肺炎链球菌所致脑膜炎病例。在指数DCC， 2个比较DCC和儿科实践中进行鼻咽样本培养。用脉冲场凝胶电泳（PFGE）和smi对分离株进行血清分型和亚型分型，3个DCC的肺炎球菌携带率为44%-65%，儿科为29%，在3个DCC中，13%-19%的儿童携带多药耐药血清型14s肺炎，PFGE在指数DCC和1个其他DCC中鉴定出爆发菌株；在第三例DCC中发现了一种密切相关的菌株，爆发菌株的携带与0-24个月的年龄、抗生素使用、上呼吸道感染和中耳炎有关，对患病儿童的DCC接触者给予利福平和克林霉素化学预防，这产生了深远但短暂的携带减少。没有发生其他病例。
Three cases of meningitis due to multidrug-resistant serotype 14 Streptococcus pneumoniae occurred at a day care center (DCC) over 5 days. Cultures of nasopharyngeal samples were done at the index DCC, 2 comparison DCCs, and a pediatrics practice. Isolates were serotyped and subtyped by pulsed-field gel electrophoresis (PFGE) with SmaI, Pneumococcal carriage rates ranged from 44%-65% at the 3 DCCs and 29% in the pediatrics practice, Carriage of multidrug-resistant serotype 14 S, pneumoniae was noted in 13%-19% of children at the 3 DCCs, An outbreak strain was identified by PFGE at the index DCC and 1 other DCC; a closely related strain was found in the third DCC, Carriage of the outbreak strain Was associated with being age 0-24 months, antibiotic use, upper respiratory tract infections, and otitis media, DCC contacts of the ill children were offered chemoprophylaxis with rifampin and clindamycin, which produced a profound but transient decrease in carriage. No additional cases occurred.