Effect of bicarbonate on efficacy of oral rehydration therapy: studies in an experimental model of secretory diarrhoea.
Effect of bicarbonate on efficacy of oral rehydration therapy: studies in an experimental model of secretory diarrhoea.
复制标题
碳酸氢盐对口服补液疗法疗效的影响：分泌性腹泻实验模型的研究。
作者：
E. Elliott;A. Watson;J. A. Walker;M. Farthing
大鼠小肠原位灌注用于评价碳酸氢盐对低钠（35 mmol/l）葡萄糖电解质口服补液溶液在正常和霍乱毒素处理的大鼠小肠中的功效的影响。在正常肠中，水的吸收更大（108（8.1）微升/分钟/克; p小于0.01）和钠分泌较少（-4.3（0.3）μ mol/min/g; p小于0.01），而不是其中碳酸氢根被氯离子替代的溶液（分别为59.5（7.2）微升/分钟/克和-7.8（0.8）μ mol/分钟/克）。两种溶液在正常肠道中的葡萄糖吸收相似。在分泌肠中，两种口服补液溶液都将净水分泌逆转为吸收，但包含碳酸氢盐导致两种水的净吸收显著减少（2.18（6.9）微升/分钟/克; p小于0.05）和葡萄糖（18.7（2.1）μ mol/min/g; p <0.001），与无碳酸氢盐口服补液溶液（分别为19.4（3.9）μ L/min/g和35.8（3.7）μ mol/min/g）相比。净钠分泌发生在正常和分泌肠，但显着减少与含碳酸氢盐的口服补液溶液。这些发现表明，碳酸氢盐在促进正常大鼠肠道从该口服补液溶液中吸收水方面的明显优势不适用于霍乱毒素处理的分泌肠。
In situ perfusion of rat intestine was used to evaluate the effect of bicarbonate on the efficacy of a low sodium (35 mmol/l) glucose-electrolyte oral rehydration solution in normal and cholera toxin-treated rat small intestine. In normal intestine, absorption of water was greater (108 (8.1) microliters/min/g; p less than 0.01) and sodium secretion less (-4.3 (0.3) mumol/min/g; p less than 0.01) from the oral rehydration solution containing bicarbonate than from the solution in which bicarbonate was replaced by chloride ions (59.5 (7.2) microliters/min/g and -7.8 (0.8) mumol/min/g, respectively). Glucose absorption in normal intestine was similar with both solutions. In the secreting intestine, both oral rehydration solutions reversed net water secretion to absorption, but inclusion of bicarbonate resulted in significantly less net absorption of both water (2.18 (6.9) microliters/min/g; p less than 0.05) and glucose (18.7 (2.1) mumol/min/g; p less than 0.001) compared with bicarbonate free oral rehydration solution (19.4 (3.9) microliters/min/g and 35.8 (3.7) mumol/min/g, respectively). Net sodium secretion occurred in normal and secreting intestine but was significantly less with the bicarbonate containing oral rehydration solution. These findings suggest that the demonstrable advantage of bicarbonate in promoting water absorption from this oral rehydration solution in normal rat intestine does not apply to cholera toxin treated secreting intestine.