Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
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DOI：
10.1182/blood-2007-05-091942
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发表时间：
2007-11-15
期刊：
影响因子：
20.3
通讯作者：
Feusner, James
中科院分区：
文献类型：
--
作者：
Sung, Lillian;Lange, Beverly J.;Feusner, James
主要目的是描述在CCG2961中登记的492名急性髓系白血病儿童的微生物学定义感染和感染相关死亡率(IRM)的患病率和特征。次要目标是确定人口统计学、疾病相关和治疗变量以及感染和IRM之间的关系。机构前瞻性地记录了感染情况。检查了年龄、种族、体重指数、白血病核型、治疗和机构规模与感染结局的关系。超过60%的儿童在3个化疗阶段的每一个阶段都经历过这种感染。有58例感染性死亡；IRM的累积发病率为11%，正负2%。31%的感染性死亡与曲霉菌有关，25.9%与念珠菌有关，15.5%与甲型溶血性链球菌有关。年龄大于16岁(危险比[HR]，3.32；95%可信区间[CI]，1.87-5.89；P
The primary objective was to describe the prevalence and characteristics of microbiologically defined infections and infection-related mortality (IRM) in 492 children with acute myelold leukemia enrolled on CCG 2961. Secondary objectives were to determine the relationship between demographic, disease-related, and therapeutic variables, and infections and IRM. Institutions documented infections prospectively. Age, ethnicity, body mass index, leukemia karyotype, treatment, and institutional size were examined for association with infection outcomes. More than 60% of children experienced such infections in each of 3 phases of chemotherapy. There were 58 infectious deaths; cumulative incidence of IRM was 11% plus or minus 2%. Thirty-one percent of infectious deaths were associated with Aspergillus, 25.9% with Candida, and 15.5% with alpha hemolytic streptococcl. Age older than 16 years (hazard ratio [HR], 3.32; 95% confidence interval [CI], 1.87-5.89; P