Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Patients: A Resting-State Functional MRI Study
Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Patients: A Resting-State Functional MRI Study
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2 型糖尿病患者大脑自发活动和同步异常：静息态功能 MRI 研究
DOI：
10.3389/fnagi.2020.00181
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发表时间：
2020-06-16
影响因子：
4.8
通讯作者：
Zhang, Jiuquan
中科院分区：
文献类型：
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作者：
Liu, Daihong;Duan, Shanshan;Zhang, Jiuquan
本研究旨在探讨载脂蛋白E(APOE)-epsilon 3等位基因纯合的2型糖尿病(T2 DM)患者脑自发活动和同步性的异常情况。在APOE-epsilon 3纯合子中，包括37例T2 DM患者和37例匹配的健康对照(HC)，以获取血样测量、神经心理测试和脑功能MRI数据。采用低频波动幅度(ALFF)分析方法对自发活动异常的脑区进行识别。然后，将识别出的大脑区域作为种子，计算它们与其他大脑区域的功能连接性(FC)。两样本t检验或Mann-Whitney U检验显示两组获得性测量结果有显著差异。在T2 DM组中，利用偏相关分析探讨三种测量方法之间的潜在相关性。T2 DM组血糖水平升高，认知评估得分较低，但焦虑和抑郁测试得分较高(p<；0.05)。T2 DM组左侧枕中回的Alff较高，左侧尾状核和左侧顶下回的Fc较低(p<；0.05)。没有观察到显著的相关性。APOE-epsilon 3等位基因纯合的T2 DM患者表现出异常的大脑自发活动和与视觉相关信息处理、执行功能和负面情绪相关的大脑区域的同步性。这一发现可能会从神经影像的角度更新我们对T2 DM患者脑功能障碍机制的理解。
The study aimed to investigate the aberration of brain spontaneous activity and synchronization in type 2 diabetes mellitus (T2DM) patients homozygous for the apolipoprotein E (APOE)-epsilon 3 allele. In the APOE-epsilon 3 homozygotes, 37 T2DM patients and 37 well-matched healthy controls (HC) were included to acquire blood sample measurements, neuropsychological tests, and brain functional MRI data. The amplitude of low-frequency fluctuations (ALFF) analysis was conducted to identify the brain areas with abnormal spontaneous activity. Then, the identified brain areas were taken as seeds to compute their functional connectivity (FC) with other brain regions. The two-sample t-test or the Mann-Whitney U test were applied to reveal significant differences in acquired measurements between the two groups. The potential correlations among the three types of measurements were explored using partial correlation analysis in the T2DM group. The T2DM group had elevated glycemic levels and scored lower on the cognitive assessment but higher on the anxiety and depression tests (p < 0.05). The T2DM group exhibited higher ALFF in the left middle occipital gyrus, and the left middle occipital gyrus had lower FC with the left caudate nucleus and the left inferior parietal gyrus (p < 0.05). No significant correlations were observed. T2DM patients homozygous for the APOE-epsilon 3 allele exhibited aberrant brain spontaneous activity and synchronization in brain regions associated with vision-related information processing, executive function, and negative emotions. The findings may update our understanding of the mechanisms of brain dysfunction in T2DM patients in a neuroimaging perspective.