Dramatic changes in muscle contractile and structural properties after 2 botulinum toxin injections.
Dramatic changes in muscle contractile and structural properties after 2 botulinum toxin injections.
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DOI：
10.1002/mus.24576
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发表时间：
2015-10
期刊：
影响因子：
3.4
通讯作者：
Ward SR
中科院分区：
文献类型：
--
作者：
Minamoto VB;Suzuki KP;Bremner SN;Lieber RL;Ward SR
肉毒杆菌毒素经常连续给药以维持治疗性肌肉麻痹，但重复给药对肌肉功能的影响在很大程度上是未知的。本研究表征了对间隔3个月的2次肉毒毒素（BoNT）注射的肌肉反应。动物受试者接受单次毒素注射（n=8），间隔3个月的2次BoNT注射（n= 14），或间隔3个月的1次BoNT和1次盐水注射（n=8）。2次连续注射的功能效应以指数方式大于单次注射的效应。虽然用单次BoNT注射处理的两个组在注射腿中的扭矩相对于对侧腿降低了约50%，但是双次BoNT注射组相对于注射前水平降低了超过95%的扭矩。单次和双次BoNT注射都产生了纤维型分组的明显迹象。这些实验证明第二次BoNT注射的效果不成比例地增加。
Botulinum toxin is frequently administered serially to maintain therapeutic muscle paralysis, but repeated dose effects on muscle function are largely unknown. This study characterized the muscle response to 2 onabotulinum toxin (BoNT) injections separated by 3 months. Animal subjects received a single toxin injection (n=8), 2 BoNT injections separated by 3 months (n= 14), or 1 BoNT and 1 saline injection separated by 3 months (n=8). The functional effect of 2 serial injections was exponentially greater than the effect of a single injection. While both groups treated with a single BoNT injection had decreased torque in the injected leg by about 50% relative to contralateral legs, the double BoNT injected group had decreased torque by over 95% relative to the pre-injection level. Both single and double BoNT injections produced clear signs of fiber-type grouping. These experiments demonstrate a disproportionately increased effect of a second BoNT injection.