Chronic Rhinosinusitis with Nasal Polyps.
Chronic Rhinosinusitis with Nasal Polyps.
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DOI：
10.1016/j.jaip.2016.04.012
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Kern RC
中科院分区：
文献类型：
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作者：
Stevens WW;Schleimer RP;Kern RC
慢性鼻窦炎伴鼻息肉（CRSwNP）是一种重要的临床实体，通过慢性鼻窦炎的主观和客观证据的存在来诊断。症状包括持续超过12周的前部或后部鼻漏、鼻塞、嗅觉减退和/或面部压力或疼痛。鼻息肉是一种炎性病变，突出到鼻气道，通常是双侧的，起源于筛窦。男性比女性更容易受到影响，但迄今为止，没有特定的遗传或环境因素与这种疾病的发展密切相关。CRSwNP经常与哮喘和过敏性鼻炎相关，但导致临床症状的细胞和分子机制尚未完全了解。鼻窦上皮细胞屏障的缺陷、致病菌和定植菌的暴露增加以及宿主免疫系统的失调都被认为在疾病发病机制中起重要作用。需要更多的研究来进一步探索CRSwNP的临床和病理生理学特征，以便可以识别生物标志物并取得新的进展来改善这种疾病的治疗和管理。
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed by the presence of both subjective and objective evidence of chronic sinonasal inflammation. Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia and/or facial pressure or pain that last for greater than 12 weeks duration. Nasal polyps are inflammatory lesions that project into the nasal airway, are typically bilateral, and originate from the ethmoid sinus. Males are more likely to be affected than females but no specific genetic or environmental factors have been strongly linked to the development of this disorder to date. CRSwNP is frequently associated with asthma and allergic rhinitis but the cellular and molecular mechanisms that contribute to the clinical symptoms are not fully understood. Defects in the sinonasal epithelial cell barrier, increased exposure to pathogenic and colonized bacteria, and dysregulation of the host immune system are all thought to play prominent roles in disease pathogenesis. Additional studies are needed to further explore the clinical and pathophysiological features of CRSwNP so that biomarkers can be identified and novel advances can be made to improve the treatment and management of this disease.