Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment

Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment
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外泌体长非编码RNA:生物学特性和癌症治疗潜力

DOI:
10.1631/jzus.b1900039
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发表时间:
2019-05
影响因子:
5.1
通讯作者:
Lin Aifu
Lin Aifu
中科院分区:
生物学2区
文献类型:
--
作者:
Luo Jie;Xiong Yan;Fu Peifen;Li Enchun;Qu Lei;Fan Xiao;Cai Zhijian;Lin Aifu

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外泌体和长链非编码RNA(lncRNA)正在成为有助于更全面了解癌症发展和进展的重要因素。lncRNA在外来体中的发现进一步表明了它们在癌症发展和耐药性中真正的生物学功能作用。本文综述了exosomelncRNAs的生物学起源及其在肿瘤研究中的作用。这些发现显著地推进了目前对外泌体lncRNA的认识,并表明它们可能是有前途的癌症诊断生物标志物和治疗靶点。
Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
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