Allylic Amination of Highly Substituted Alkenes Enabled by Photoredox Catalysis and Cu(II)-Mediated Radical-Polar Crossover.
Allylic Amination of Highly Substituted Alkenes Enabled by Photoredox Catalysis and Cu(II)-Mediated Radical-Polar Crossover.
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通过光氧化还原催化和 Cu(II) 介导的自由基-极性交叉实现高度取代烯烃的烯丙基胺化。
DOI：
10.1021/acs.orglett.3c01774
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发表时间：
2023
期刊：
影响因子：
5.2
通讯作者：
Yoon,TehshikP
中科院分区：
文献类型：
--
作者：
Lutovsky,GraceA;Plachinski,EllieF;Reed,NicholasL;Yoon,TehshikP
烯丙基胺化反应能够将烯烃原料转化为具有显著合成通用性的增值产品。在这里，我们描述了一种方法烯丙基胺化涉及光氧化还原活化和Cu（II）介导的自由基极性交叉。使用这种策略可以获得一系列结构不同的烯丙基胺。该方法的区域选择性与传统的烯丙基胺化方法是互补的。
Allylic amination reactions enable the conversion of alkene feedstocks into value-added products with significant synthetic versatility. Here we describe a method for allylic amination involving photoredox activation and Cu(II)-mediated radical–polar crossover. A range of structurally varied allylic amines can be accessed using this strategy. The regioselectivity of this process is complementary to those of conventional methods for allylic amination.