Effects on developmental landmarks and reproductive capability of 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′,5-pentacholorobiphenyl in offspring of rats exposed during pregnancy
Effects on developmental landmarks and reproductive capability of 3,3′,4,4′-tetrachlorobiphenyl and 3,3′,4,4′,5-pentacholorobiphenyl in offspring of rats exposed during pregnancy
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DOI：
10.1191/096032798678908954
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发表时间：
1998-07-01
影响因子：
2.8
通讯作者：
Chahoud, I
中科院分区：
文献类型：
--
作者：
Faqi, AS;Dalsenter, PR;Chahoud, I
1 怀孕 Wistar 大鼠口服单剂量 100 μg 3,3',4,4'-四氯联苯 (PCB 77)/kg b.w。或 10 微克 3,3',4,4',5 五氯联苯 (PCB 126)/公斤体重怀孕第15天。对照组大鼠在同一天接受花生油。对所有子代大鼠的发育标志进行了评估，并在出生后第 65 天（青春期）和出生后第 140 天（成年期）研究了 PCE 77 和 PCE 126 对雄性后代的生殖影响。2 PCB 126 组雄性幼鼠的肛门生殖器距离以及肛门生殖器距离与身体长度的比率减小，阴道开口年龄显着降低。 雌性幼仔的延迟。3 PCB 77 组的雄性后代的睾丸、大脑重量和每日精子产量永久性增加，精囊重量减少。 PCB 126组雄性大鼠的脑重量永久增加，腹侧前列腺重量永久减少。然而，在两个 PCB 组中，血清睾酮浓度仅在成年时降低，此外，PCB 126 组的雄性大鼠表现出性行为的改变，在这些大鼠中，插入的数量显着增加。 4 这项研究的结果表明，PCB 126 在子宫内暴露后会引起一些类似 TCDD 的生殖效应，而子宫内暴露于 PCB 的生殖效应 77 对男性后代的影响可能是由于该物质在胎儿早期发育过程中引起的新生儿甲状腺功能减退所致。需要使用多剂量并提供甲状腺激素数据的进一步研究来支持这一假设。
1 Pregnant Wistar rats were treated orally with a single dose of 100 mu g 3,3',4,4'-tetrachlorobiphenyl (PCB 77)/ kg b.w. or 10 mu g 3,3',4,4',5 pentachlorobiphenyl (PCB 126)/kg b.w. on day 15 of pregnancy. The control rats received peanut oil at the same day. Developmental landmarks were assessed in all offspring rats and reproductive effects of PCE 77 and PCE 126 on male offspring were studied on postnatal day 65 (at puberty) and on postnatal day 140 (at adulthood).2 The ano-genital distance as well as the ratio anogenital distance to body length was reduced in male pups of the PCB 126 group and the age at vaginal opening was significantly delayed in the female pups.3 Testis, brain weights and daily sperm production were permanently increased and seminal vesicle weights were decreased in male offspring of the PCB 77 group. In male rats of PCB 126 group, the brain weights were permanently increased and ventral prostate weights permanently reduced. In both PCB groups, however, serum testosterone concentration was reduced only at adulthood, Additionally, the male rats of the PCB 126 group showed alterations in sexual behavior, In these rats the number of mounts with intromissions was significantly increased.4 The results of this study show that PCB 126 elicits some TCDD-like reproductive effects after in utero exposure, while the reproductive effects of in utero exposure to PCB 77 on male offspring may be attributed to the neonatal hypothyroidism induced by the substance during early fetal development. Further studies using multiple doses and providing thyroid hormone data will be necessary to support this hypothesis.