Static and pulsatile intracranial pressure in idiopathic intracranial hypertension
Static and pulsatile intracranial pressure in idiopathic intracranial hypertension
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DOI：
10.1016/j.clineuro.2010.10.008
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发表时间：
2011-02-01
影响因子：
1.9
通讯作者：
Kerty, Emilia
中科院分区：
文献类型：
--
作者：
Eide, Per Kristian;Kerty, Emilia
目的：本观察性研究的目的是描述保守（医学）治疗的特发性颅内高压（IIH）患者需要分流手术的静态和脉动性颅内压（ICP），以及无视觉障碍的慢性每日头痛（CDH）患者。方法：选取14例IIH患者和7例CDH患者，连续夜间监测ICP。静态ICP以平均ICP为特征，脉动ICP以波幅、上升时间和上升时间系数为特征。结果：IIH组14例患者均有头痛和视觉障碍。平均ICP高（>= 15 mmHg）仅7例（50%），而平均ICP波幅高（>= 4 mmHg） 14例（100%）。所有IIH患者均接受分流治疗并在临床得到改善（即视力障碍和/或头痛缓解）。CDH组均无高平均颅内压或平均颅内压波幅，无分流。结论：在14例持续分流反应性头痛和视觉障碍的IIH患者中，尽管平均ICP正常，但所有患者的平均ICP波幅均升高（>= 4 mmHg）。
Objective: The aim of this observational study was to characterize the static and pulsatile intracranial pressure (ICP) in conservatively (medically) treated idiopathic intracranial hypertension (IIH) patients in need of shunt surgery, and also in patients with chronic daily headache (CDH) without visual disturbances.Methods: The material includes 14 IIH patients and 7 CDH patients in whom ICP was monitored continuously over-night. Static ICP was characterized by mean ICP, pulsatile ICP was characterized by the wave amplitude, rise time, and rise time coefficient.Results: In the IIH group all 14 had headache and visual disturbances. Mean ICP was high (>= 15 mmHg) in only 7 patients (50%), while mean ICP wave amplitude was high (>= 4 mmHg) in all 14 (100%). All IIH patients were shunted and improved clinically thereafter (i.e., relief from visual disturbances and/or headache). None in the CDH group had high mean ICP or mean ICP wave amplitude, and none were shunted.Conclusions: In this cohort of 14 conservatively treated IIH patients with lasting and shunt-responsive headache and visual disturbances, the mean ICP wave amplitude was elevated (>= 4 mmHg) in all patients despite normal mean ICP (