Intracranial electroencephalography power and phase synchronization changes during monaural and binaural beat stimulation
Intracranial electroencephalography power and phase synchronization changes during monaural and binaural beat stimulation
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DOI：
10.1111/ejn.12760
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发表时间：
2015-01-01
影响因子：
3.4
通讯作者：
Fell, Juergen
中科院分区：
文献类型：
--
作者：
Becher, Ann-Katrin;Hoehne, Marlene;Fell, Juergen
用单耳或双耳听觉节拍（即，分别向双耳或每只耳朵呈现具有附近频率的正弦波）进行听觉刺激代表了影响脑电活动的非侵入性方法。目前还不清楚哪些大脑部位会受到心跳刺激的影响。特别是，搏动刺激对中颞叶脑区的影响可能为记忆增强或癫痫控制提供新的选择。因此，我们基于手术前癫痫患者的颅内记录，研究了如何通过具有与主导脑电节律相对应的拍频的听觉刺激来调制脑电（EEG）功率和相位同步。单耳和双耳节拍刺激与5，10，40和80 Hz的拍频和非叠加的控制信号，以低幅度（60 dBSPL）和短的持续时间（5秒）。脑电功率从颞中，颞基底和颞侧和表面网站颅内记录。通过使用Bonferroni校正的非参数标记排列检验，比较了搏动与控制刺激期间的诱发和总EEG功率和相位同步。我们发现，功率和相位同步显着调制节拍刺激不仅在颞基底，颞侧和表面网站，但也在颞中的网站。总体而言，观察到的下降幅度大于上升幅度。最显着的功率增加后，看到单耳40 Hz的节拍刺激。最明显的功率和同步性下降导致单耳5赫兹和双耳80赫兹的节拍刺激。我们的研究结果表明，搏动刺激提供了一个非侵入性的方法调制颅内脑电图的特点。
Auditory stimulation with monaural or binaural auditory beats (i.e. sine waves with nearby frequencies presented either to both ears or to each ear separately) represents a non-invasive approach to influence electrical brain activity. It is still unclear exactly which brain sites are affected by beat stimulation. In particular, an impact of beat stimulation on mediotemporal brain areas could possibly provide new options for memory enhancement or seizure control. Therefore, we examined how electroencephalography (EEG) power and phase synchronization are modulated by auditory stimulation with beat frequencies corresponding to dominant EEG rhythms based on intracranial recordings in presurgical epilepsy patients. Monaural and binaural beat stimuli with beat frequencies of 5, 10, 40 and 80Hz and non-superposed control signals were administered with low amplitudes (60dBSPL) and for short durations (5s). EEG power was intracranially recorded from mediotemporal, temporo-basal and temporo-lateral and surface sites. Evoked and total EEG power and phase synchronization during beat vs. control stimulation were compared by the use of Bonferroni-corrected non-parametric label-permutation tests. We found that power and phase synchronization were significantly modulated by beat stimulation not only at temporo-basal, temporo-lateral and surface sites, but also at mediotemporal sites. Generally, more significant decreases than increases were observed. The most prominent power increases were seen after stimulation with monaural 40-Hz beats. The most pronounced power and synchronization decreases resulted from stimulation with monaural 5-Hz and binaural 80-Hz beats. Our results suggest that beat stimulation offers a non-invasive approach for the modulation of intracranial EEG characteristics.