Dermal-resident CD14+ cells:: differentiate into Langerhans cells
Dermal-resident CD14+ cells:: differentiate into Langerhans cells
复制标题
DOI：
10.1038/ni731
复制
发表时间：
2001-12-01
影响因子：
30.5
通讯作者：
Falo, LD
中科院分区：
文献类型：
--
作者：
Larregina, AT;Morelli, AE;Falo, LD
表皮Langerhans细胞（LCS）表现出非凡的免疫刺激能力，并在免疫反应的启动和调节中起关键作用。 LC生物学的研究目前是设计免疫反应并更好地了解皮肤疾病的免疫病理学的重点。在这里，我们确定并表征了居住在人皮肤中的LC前体的种群。这些直接的前体表示CD14，Langerin和功能CCR6。当单独转化生长因子-beta1培养时，它们有可能区分表皮LC。当在存在粒细胞巨噬细胞 - 粘合剂刺激因子和白介素4中培养时，它们分化为功能成熟的树突状细胞。这些LC前体的识别和表征提供了对LC生物学的见解以及LCS重新填充表皮的机制。
Epidermal Langerhans cells (LCs) show extraordinary immunostimulatory capacity and play a key role in the initiation and regulation of immune responses. Studies of LC biology are currently the focus of efforts to engineer immune responses and to better understand the immunopathology of cutaneous diseases. Here we identified and characterized a population of LC precursors that were resident in human skin. These immediate precursors expressed CD14, langerin and functional CCR6. When cultured with transforming growth factor-beta1 alone, they had the potential to differentiate into epidermal LCs; when cultured in the presence of granulocyte macrophage-colony-stimulating factor and interleukin 4 they differentiated into functionally mature dendritic cells. Identification and characterization of these LC precursors provided insight into LC biology and the mechanism(s) through which LCs repopulate the epidermis.