LUNG DENSITY AND LUNG MASS IN EMPHYSEMA
LUNG DENSITY AND LUNG MASS IN EMPHYSEMA
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DOI：
10.1378/chest.102.1.198
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发表时间：
1992-07-01
期刊：
影响因子：
9.6
通讯作者：
VERGERET, J
中科院分区：
文献类型：
--
作者：
GUENARD, H;DIALLO, MHH;VERGERET, J
可以使用CT扫描数据计算平均肺密度（dm）和放射学（VLx）肺体积。 由于许多肺气肿患者过度膨胀，单独分析dm可能没有意义。 然而，肺质量（m）可以计算为dm和VLx的乘积。 24例疑似轻度或重度肺气肿的患者（通过X线和生理检查判断）以及16例健康受试者纳入该方案。 他们都进行了CT扫描的全肺和功能测试，从以下推导出：气道阻力，用力呼气容积1秒（FEV 1），用力肺活量（FVC），总肺容量（TLC），CO转移能力，准静态功能残气量（FRC）的顺应性，和血气。 所有CT扫描均在每例患者的FRC处进行。 肺气肿患者的dm低于健康受试者，因为患者的m大于健康受试者;分别为1，303 +/- 398 g和997 +/- 133 g。 虽然dm值与FEV 1、FEV 1/FVC和TLC显著相关，但m值与这些功能指标均不相关。 出乎意料的是，这些结果表明，大多数肺气肿患者（22/24）的肺质量正常或增加。 正常或高于正常的m值可能是由于某些患者分泌过多。 然而，由于慢性炎症导致的新组织合成是最有可能解释这一发现的原因。
Mean lung density (dm) and radiologic (VLx) lung volume can be calculated using CT scan data. As many emphysematous patients are overdistended, the analysis of dm alone could be meaningless. However, lung mass (m) can be calculated as the product of dm and VLx. Twenty-four patients suspected of mild or severe emphysema as judged by roentgenographic and physiologic examinations as well as 16 healthy subjects were included in the protocol. They all underwent both a CT scan of the whole lung and functional tests from which the following were derived: airway resistance, forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC), CO transfer capacity, quasistatic compliance at functional residual capacity (FRC), and blood gases. All CT scans were performed at the FRC of each patient. The dm was lower in emphysema patients than in healthy subjects, as m was greater in patients than in healthy subjects; 1,303 +/- 398 g and 997 +/- 133 g, respectively. Although dm values were significantly correlated to FEV1, FEV1/FVC, and TLC, m values were not correlated to any of these functional indices. Unexpectedly, these results show that most patients (22/24) with emphysema have a normal or increased lung mass. Normal or above normal m values might be due to oversecretion in some patients. Nevertheless, the synthesis of new tissue due to chronic inflammation is the most likely explanation that could account for this finding.