Functional adaptation of interradicular alveolar bone to reduced chewing loads on dentoalveolar joints in rats.
Functional adaptation of interradicular alveolar bone to reduced chewing loads on dentoalveolar joints in rats.
复制标题
大鼠根间牙槽骨对减轻牙槽关节咀嚼负荷的功能适应。
DOI：
10.1016/j.dental.2020.12.003
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Ho SP
中科院分区：
文献类型：
--
作者：
Jang A;Wang B;Ustriyana P;Gansky SA;Maslenikov I;Useinov A;Prevost R;Ho SP
本文研究了降低咀嚼负荷对大鼠牙槽关节内根间骨（IB）承载完整性的影响。将4周龄的Sprague道利大鼠（N = 60）分成两组;大鼠被喂食正常食物，即硬颗粒食物（HF）（N = 30）或软粉末食物（SF）（N = 30）。完整的DAJ的生物力学测试和映射内IB从8- 24周龄大鼠喂食HF或SF的机械应变进行。拉伸和压缩为基础的机械应变分布映射相关的数字体积的IB在无负荷下与相同的IB负荷。通过使用组织学绘制骨水泥线和TRAP阳性多核细胞以及使用纳米压痕技术绘制机械性能来鉴定IB内的异质性。SF组与HF组相比，根间功能间隙、IB体积分数和IB弹性模量显著降低，这些趋势随着年龄的增加而变化。弹性模量值显示出HF或SF组IB内的显著异质性。基于压缩和张力的应变均位于IB的冠状部分，应变曲线的变化补充了使用组织学和纳米压痕观察到的材料异质性。DAJ中的根间隙和IB材料相关的机械适应性被优化以满足与软食物相关的咀嚼需求。结果提供了见解的年龄特异性调节的咀嚼负荷作为一个合理的“治疗剂量”，以扭转适应牙周复合体内，试图重新获得功能能力的动态DAJ。
The effects of reduced chewing loads on load bearing integrity of interradicular bone (IB) within dentoalveolar joints (DAJ) in rats were investigated. Four-week-old Sprague Dawley rats (N = 60) were divided into two groups; rats were either fed normal food, which is hard-pellet food (HF) (N = 30), or soft-powdered chow (SF) (N = 30). Biomechanical testing of intact DAJs and mapping of the resulting mechanical strains within IBs from 8- through 24-week-old rats fed HF or SF were performed. Tension- and compression-based mechanical strain profiles were mapped by correlating digital volumes ofIBs at no load with the same IBs under load. Heterogeneity within IB was identified by mapping cement lines and TRAP-positive multinucleated cells using histology, and mechanical properties using nanoindentation technique. Significantly decreased interradicular functional space, IB volume fraction, and elastic modulus of IB in the SF group compared with the HF group were observed, and these trends varied with an increase in age. The elastic modulus values illustrated significant heterogeneity within IB from HF or SF groups. Both compression- and tension-based strains were localized at the coronal portion of the IB and the variation in strain profiles complemented the observed material heterogeneity using histology and nanoindentation. Interradicular space and IB material-related mechanoadaptations in a DAJ are optimized to meet soft food related chewing demands. Results provided insights into age-specific regulation of chewing loads as a plausible “therapeutic dose” to reverse adaptations within the periodontal complex as an attempt to regain functional competence of a dynamic DAJ.
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DOI：
10.1016/s0889-5406(95)70089-7
发表时间：
1995-04-01
影响因子：
3
作者：
KILIARIDIS, S;TZAKIS, MG;CARLSSON, GE
通讯作者：
CARLSSON, GE
影响因子：
3.7
作者：
Leong, Narita L.;Hurng, Jonathan M.;Ho, Sunita P.
通讯作者：
Ho, Sunita P.
影响因子：
4.9
作者：
Ho, SP;Balooch, M;Marshall, GW
通讯作者：
Marshall, GW
影响因子：
3
作者：
Naveh, Gili R. S.;Shahar, Ron;Weiner, Steve
通讯作者：
Weiner, Steve
影响因子：
3.5
作者：
Niver, E. L.;Leong, N.;Ho, S. P.
通讯作者：
Ho, S. P.