Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.
Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.
复制标题
艰难梭菌毒素葡萄糖基转移酶的致病作用。
DOI：
10.1093/femspd/ftw024
复制
发表时间：
2016
影响因子：
3.3
通讯作者：
Feng,Hanping
中科院分区：
文献类型：
--
作者：
Zhang,Yongrong;Feng,Hanping
The glucosyltransferase domain ofClostridium difficiletoxins modifies guanine nucleotide-binding proteins of Rho family. It is the major virulent domain of the holotoxins. Various pathogenic effects ofC. difficiletoxins in response to Rho glucosylation have been investigated including cytoskeleton damage, cell death and inflammation. The most recent studies have revealed some significant characteristics of the holotoxins that are independent of glucosylating activity. These findings arouse discussion about the role of glucosyltransferase activity in toxin pathogenesis and open up new insights for toxin mechanism study. In this review, we summarize the pathogenic effects of glucosyltransferase domain of the toxins in the past years.
