Self-Assembling Peptide-Based Delivery of Therapeutics for Myocardial Infarction
Self-Assembling Peptide-Based Delivery of Therapeutics for Myocardial Infarction
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DOI：
10.1007/978-1-4939-0363-4_10
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Davis, Michael E.
中科院分区：
文献类型：
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作者：
Boopathy, Archana V.;Davis, Michael E.
药物和细胞传递系统可以被调节，以作为再生医学中的指导性微环境。为此，已经开发了几种合成生物材料来模拟用于治疗用途的天然细胞外基质（ECM）。这些包括具有不同应用的合成聚合物、脱细胞ECM、自组装聚合物和细胞响应性水凝胶。在这里，我们描述了一种自组装肽水凝胶的发展及其作为细胞和生长因子递送载体到心肌梗死的啮齿动物模型中的梗死心脏的潜在用途。
Drug and cell delivery systems could be modulated to serve as instructive microenvironments in regenerative medicine. Towards this end, several synthetic biomaterials have been developed to mimic the natural extracellular matrix (ECM) for therapeutic use. These include synthetic polymers, decellularized ECM, self-assembling polymers, and cell-responsive hydrogels with varied applications. Here, we describe the development of a self-assembling peptide hydrogel and its potential use as a cell and growth factor delivery vehicle to the infarcted heart in a rodent model of myocardial infarction.