Genetic factors underlying prostate cancer.
Genetic factors underlying prostate cancer.
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DOI：
10.1017/s1462399403006057
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发表时间：
2003-04-15
影响因子：
6.2
通讯作者：
Yu, Yan Ping
中科院分区：
文献类型：
--
作者：
Luo, Jian-Hua;Yu, Yan Ping
前列腺癌是美国癌症相关死亡的主要原因之一。在过去的十年中，在识别和理解与前列腺癌发展相关的遗传因素方面取得了巨大进展。与许多其他类型的癌症不同，只有一小部分前列腺癌病例具有侵袭性并危及生命。与前列腺癌发生和进展相关的因素显得复杂多样。本综述总结了前列腺癌基因组和基因表达异常领域的一些重要发现，旨在提供这些领域新进展的全面看法。
Prostate cancer is one of the leading causes of cancer-related death in the USA. In the past decade, tremendous progress has been made in the identification and understanding of the genetic factors related to prostate cancer development. Unlike many other types of cancers, only a small fraction of prostate cancer cases are aggressive and life-threatening. The factors related to prostate cancer development and progression appear complex and diverse. This review summarises some of the important findings in the areas of genome and gene expression abnormalities in prostate cancer, and aims to provide a comprehensive view of new developments in these areas.