Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor
Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor
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DOI：
10.1039/c0cc03363d
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Julian, Ryan R.
中科院分区：
文献类型：
--
作者：
Ly, Tony;Zhang, Xing;Julian, Ryan R.
基于对碘苯甲酸酯的新型标记试剂被证明是有效的光笼前驱体，用于在气相和凝聚相中选择性地合成生物分子自由基。在真空中，一个紫外光脉冲(266 Nm)就足以定量地光解C-I键。在水溶液中，用15W紧凑型荧光灯(254 Nm)照射，光解半衰期估计为2.5分钟。
Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).