Age-dependent changes in sleep EEG topography
Age-dependent changes in sleep EEG topography
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DOI：
10.1016/s1388-2457(00)00542-3
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发表时间：
2001-02-01
影响因子：
4.7
通讯作者：
Borbély, AA
中科院分区：
文献类型：
--
作者：
Landolt, HP;Borbély, AA
目的：评估睡眠脑电图（EEG）中与年龄相关的地形变化。方法：比较年轻（平均年龄22.3岁）和中年（平均年龄62.0岁）健康男性的睡眠脑电图记录。沿前后轴的3个双极导数（额叶-中央（FC）、中央-顶叶（CP）和顶叶-枕叶（PO））获得脑电图。结果：中年组总睡眠时间、睡眠效率、第二阶段和慢波睡眠（SWS）较低，而睡眠潜伏期、入睡后第一阶段酸觉醒较高。频谱分析记录了非快速眼动睡眠 (0.25-14 Hz) 和快速眼动睡眠 (0.75-10 Hz) 中脑电图功率与年龄相关的降低。然而，3 个导数的降低并不均匀，但在 theta（两种睡眠状态）和高 α/低 Sigma 频段（非快速眼动睡眠）的前导 (FC) 中最为明显。结论：这些变化可以解释为与年龄相关的力量从前部（FC）转向中部（CP）。衰老不仅会降低睡眠脑电图的功率。但会引起大脑地形的频率特异性变化。结果与睡眠作为局部过程的概念一致。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Objective: To assess age-related topographic changes in the sleep electroencephalogram (EEG).Methods: The sleep EEG records of young (mean age. 22.3 years) and middle-aged (mean age, 62.0 years) healthy men were compared. The EEG was obtained from 3 bipolar derivations (frontal-central (FC), central-parietal (CP), and parietal-occipital (PO)) along the anteroposterior axis.Results: The total sleep time, sleep efficiency, stage 2 and slow wave sleep (SWS) were lower in the middle-aged group, while sleep latency, stage I acid wakefulness after sleep onset were higher. Spectral analysis documented the age-related reduction of EEG power in non-REM sleep (0.25-14 Hz), and REM sleep (0.75-10 Hz), However, the reduction was not uniform over the 3 derivations, but was most pronounced in the anterior derivation (FC) in the theta (both sleep states) and high-alpha/low-sigma bands (non-REM sleep).Conclusions: These changes can be interpreted as age-related shifts of power from the anterior (FC) towards the middle derivation (CP). Aging not only reduces power in the sleep EEG. but causes frequency-specific changes in the brain topography. The results are consistent with the notion of sleep as a local process. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.