Novel therapeutic strategies for malignant salivary gland tumors: lessons learned from breast cancer.
Novel therapeutic strategies for malignant salivary gland tumors: lessons learned from breast cancer.
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DOI：
10.1155/2011/187623
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发表时间：
2011
影响因子：
--
通讯作者：
Desprez PY
中科院分区：
文献类型：
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作者：
Murase R;Sumida T;Ishikawa A;Murase R;McAllister SD;Hamakawa H;Desprez PY
恶性唾液腺肿瘤（MSGTs）占所有头颈部癌症的2-6%。尽管罕见，但由于多种病理特征和高转移率导致预后不良，MSGTs一直受到极大关注。手术切除后放射治疗是这种恶性肿瘤的主要治疗方法。辅助治疗保留用于局部复发的管理，不再适合额外的局部治疗和转移。基于对其他类型肿瘤，特别是乳腺癌的研究，性类固醇激素受体在肿瘤中的表达和功能已被广泛研究并应用于诊断和治疗。虽然已经发表了一些关于MSGTs的研究，但由于结果不同和病例数量不足，激素治疗的基本原理仍然存在争议。然而，最近的一些报道表明，某些唾液腺肿瘤与乳腺癌相似，不仅在病理特征方面，而且在分子水平上。在这里，我们阐明了MSGTs和某些类型的乳腺癌之间的生物学相似性，并描述了MSGTs的激素和其他疗法的潜在用途。
Malignant salivary gland tumors (MSGTs) account for 2–6% of all head and neck cancers. Despite the rarity, MSGTs have been of great interest due to a wide variety of pathological features and high metastasis rates resulting in poor prognosis. Surgical resection followed by radiation therapy represents the main treatment of this malignancy. Adjuvant therapy is reserved for the management of local recurrence, no longer amenable to additional local therapy, and for metastasis. Based on the studies from other types of tumors, particularly breast cancer, the expression and function of sex steroid hormone receptors in cancer have been extensively studied and applied to diagnosis and treatment. Although a number of studies in MSGTs have been published, the rationale for hormone therapy is still controversial due to the disparate results and insufficient number of cases. However, some recent reports have demonstrated that certain salivary gland neoplasms are similar to breast cancer, not only in terms of the pathological features, but also at the molecular level. Here, we shed light on the biological similarity between MSGTs and certain types of breast cancer, and describe the potential use of hormone and additional therapies for MSGTs.