Metabolic control of tumour progression and antitumour immunity.
Metabolic control of tumour progression and antitumour immunity.
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DOI：
10.1097/cco.0000000000000035
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发表时间：
2014-01
影响因子：
3.4
通讯作者：
Mellor AL
中科院分区：
文献类型：
--
作者：
Huang L;Mellor AL
Loss of cell growth control does not explain why tumors form as the immune system recognizes many malignant cells and keeps them in check. The local inflammatory microenvironment is a pivotal factor in tumor formation as tumor associated inflammation actively suppresses anti-tumor immunity. The purpose of this review is to evaluate emerging evidence that amino acid catabolism is a key feature of tumor-associated inflammation that supports tumor progression and immune resistance to therapy. Enhanced amino acid catabolism in inflammatory tumor microenvironments correlates with carcinogen resistance and immune regulation mediated by tumor-associated immune cells that protect tumors from natural and vaccine-induced immunity. Interfering with metabolic pathways exploited by tumors is a promising anti-tumor strategy, especially when combined with other therapies. Moreover, molecular sensors that evolved to detect pathogens may enhance evasion of immune surveillance to permit tumor progression. Innate immune sensing that induces amino acid catabolism in tumor microenvironments may be pivotal in initiating and sustaining local inflammation that promotes immune resistance and attenuates anti-tumor immunity. Targeting molecular sensors that mediate these metabolic changes may be an effective strategy to enhance anti-tumor immunity that prevents tumor progression, as well as improving the efficacy of cancer therapy.
