Myocardial and Microvascular Injury Due to Coronavirus Disease 2019
Myocardial and Microvascular Injury Due to Coronavirus Disease 2019
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DOI：
10.15420/ecr.2020.22
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发表时间：
2020-01-01
影响因子：
3
通讯作者：
Niccoli, Giampaolo
中科院分区：
文献类型：
--
作者：
Montone, Rocco A.;Iannaccone, Giulia;Niccoli, Giampaolo
在过去的几个月里，全球卫生系统受到了由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）大流行的考验。尽管SARSCoV-2感染的主要临床表现涉及呼吸道，但全身受累导致多器官衰竭发作并导致致命后果的风险不可忽略。自COVID-19爆发以来，患有基础心血管疾病的患者临床结局不良的风险增加，死亡率更高。此外，在因COVID-19住院的患者中，新发心脏并发症的发生并不罕见。重要的是，很大一部分COVID-19患者存在心肌损伤。本文就SARS冠状病毒2型感染导致心肌和微血管损伤的机制及其临床意义进行了讨论。
Over the past few months, health systems worldwide have been put to the test with the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though the leading clinical manifestations of the SARSCoV-2 infection involve the respiratory tract, there is a non-negligible risk of systemic involvement leading to the onset of multi-organ failure with fatal consequences. Since the onset of COVID-19, patients with underlying cardiovascular disease have been at increased risk of poor clinical outcomes with higher death rates. Moreover, the occurrence of new-onset cardiac complications is not uncommon among patients hospitalised for COVID-19. Of importance, a significant portion of COVID-19 patients present with myocardial injury. Herein, the authors discuss the mechanisms leading to myocardial and microvascular injury in SARS-CoV-2 infection and their clinical implications.