Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation.
Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation.
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DOI：
10.1002/cam4.117
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发表时间：
2013-10
期刊：
影响因子：
4
通讯作者：
Aoki, Kazunori
中科院分区：
文献类型：
--
作者：
Suzuki, Koji;Aida, Kouichirou;Miyakawa, Reina;Narumi, Kenta;Udagawa, Takeshi;Yoshida, Teruhiko;Ohshima, Yusei;Aoki, Kazunori
Lymphopenia-induced homeostatic proliferation (HP) of T cells following autologous hematopoietic stem cell transplantation (HSCT) skews the T-cell repertoire by engaging tumor-associated antigens (TAAs), leading to an induction of antitumor immunity. Here, as the tumor-reactive lymphocytes preferentially proliferate during the condition of HP, we examined whether the priming of a donor lymphocytes to TAAs could enhance HP-induced antitumor immunity in autologous HSCT recipients. First, to examine whether the tumor-bearing condition of donor influences the antitumor effect of HSCT, the lymphocytes isolated from CT26 tumor-bearing mice were infused into lethally irradiated mice. The growth of tumors was substantially suppressed in the mice that received HSCT from a tumor-bearing donor compared with a naïve donor, suggesting that a fraction of donor lymphocytes from tumor-bearing mice are primed in response to TAAs and remain responsive upon transplantation. We previously reported that type I interferon (IFN) maturates the dendritic cells and promotes the priming of T cells. We then investigated whether the further priming of donor cells by IFN-α can strengthen the antitumor effect of HSCT. The intratumoral IFN-α gene transfer significantly increased the number of IFN-γ-positive lymphocytes in response to CT26 cells but not the syngeneic lymphocytes in donor mice. The infusion of primed donor lymphocytes markedly suppressed the tumor growth in recipient mice, and cured 64% of the treated mice. Autologous HSCT with the infusion of primed donor lymphocytes is a promising strategy to induce an effective antitumor immunity for solid cancers.
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DOI：
10.1159/000335668
发表时间：
2012-01-01
期刊：
TRANSPLANTATION DERMATOLOGY
影响因子：
--
作者：
Halter, Joerg;Passweg, Jakob;Haeusermann, Peter
通讯作者：
Haeusermann, Peter
影响因子：
20.3
作者：
Mirmonsef, Paria;Tan, Gladys;Levitsky, Hyam I.
通讯作者：
Levitsky, Hyam I.
DOI：
10.1084/jem.20041130
发表时间：
2004-09-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Turk MJ;Guevara-Patiño JA;Rizzuto GA;Engelhorn ME;Sakaguchi S;Houghton AN
通讯作者：
Houghton AN
影响因子：
5.7
作者：
Hara, Hidehiko;Kobayashi, Akihiko;Aoki, Kazunori
通讯作者：
Aoki, Kazunori
影响因子：
20.3
作者：
Borrello, Ivan M.;Levitsky, Hyam I.;Hege, Kristen M.
通讯作者：
Hege, Kristen M.