Intranasal oxytocin does not modulate jumping to conclusions in schizophrenia: Potential interactions with caudate volume and baseline social functioning
Intranasal oxytocin does not modulate jumping to conclusions in schizophrenia: Potential interactions with caudate volume and baseline social functioning
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DOI：
10.1016/j.psyneuen.2017.03.020
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发表时间：
2017-07-01
影响因子：
3.7
通讯作者：
Menon, Mahesh
中科院分区：
文献类型：
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作者：
Caravaggio, Fernando;Gerretsen, Philip;Menon, Mahesh
背景：精神分裂症(SCZ)患者在做出决定时往往样本信息较少，在没有足够证据的情况下草率下结论(JTC)。这种“JTC偏向”可能是该病的一种特征标记，抗精神病药物治疗可能不会改善这种情况。我们进行了一项双盲、安慰剂对照试验，以测试鼻腔内注射催产素是否可以降低病情稳定、服药的SCZ患者和健康对照组(HCS)的JTC。我们还探讨了纹状体体积、临床症状和基线社会功能(SF)是否与JTC表现有关。方法：43名服用药物的男性SCZ患者(平均年龄：40.81+/-11.44)和16名HCS患者(平均年龄：30.38+/-9.85)参加了一项双盲、安慰剂对照、交叉研究。参与者在两次单独的访问中完成了珠子任务(至少相隔20天)。参与者随机接受鼻腔内注射催产素(50IU溶液)或鼻腔注射安慰剂(生理盐水)。结果：SCZ患者的决策倾向(DTD)少于HCS患者(t(57)=-2.78，p=0.007)。催产素对患者的DTD无显著影响(t(42)=-1.11，p=0.27-)，对HCS患者的DTD也无显著影响(t(15)=-0.62，p=0.55)。探索性分析发现，患者腹侧尾状核体积与DTD呈负相关(r(18)=-0.50，p=0.03)。此外，在基线SF较低的患者中，催产素更有可能改善JTC。然而，这些探索性的发现并没有通过多次比较的校正。结论：我们在SCZ复制了增加的JTC。然而，急性鼻腔内催产素并不改变JTC。未来将进行更大样本的研究，探索SCZ患者的脑形态和SF与JTC表现之间的关系。
Background: Patients with schizophrenia (SCZ) tend to sample less information when making a decision, jumping to conclusions (JTC) without sufficient evidence. This "JTC bias" may be a trait marker of the disease and may not improve with antipsychotic treatment. We conducted a double-blind, placebo-controlled trial to test whether intranasal oxytocin could reduce JTC in stable, medicated patients with SCZ and healthy controls (HCs). We also explored whether striatal volume, clinical symptoms, and baseline social functioning (SF) was related to JTC performance.Methods: Forty-three male, medicated SCZ patients (Mean Age: 40.81 +/- 11.44) and sixteen HCs (Mean Age: 30.38 +/- 9.85) participated in a double-blind, placebo-controlled, cross-over study. Participants completed the Beads Task on two separate visits (minimum 20 days apart). Participants were randomized to receive either intranasal oxytocin (50IU in solution) or intranasal placebo (saline). Twenty of the SCZ patients and all sixteen HCs also provided Ti MRIs (3-T).Results: Patients with SCZ took fewer draws to decision (DTD) than HCs (t(57) = -2.78, p = 0.007). Oxytocin did not significantly change DTD in patients (t(42) = -1.11, p = 0.27-), nor in HCs (t(15) = -0.62, p = 0.55). Exploratory analyses found ventral caudate volumes were negatively correlated with DTD (r(18) = -0.50, p = 0.03) in patients. Moreover, oxytocin was more likely to improve JTC in patients with lower baseline SF. However, these exploratory findings did not survive correction for multiple comparisons.Conclusions: We replicate increased JTC in SCZ. However, acute intranasal oxytocin did not modify JTC. Future studies with larger samples should explore how brain morphology and SF are related to JTC performance in patients with SCZ.