Halothane‐Induced Liver Damage: An Analysis of the Material Reported to the Swedish Adverse Drug Reaction Committee, 1966–1973
Halothane‐Induced Liver Damage: An Analysis of the Material Reported to the Swedish Adverse Drug Reaction Committee, 1966–1973
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氟烷引起的肝损伤：对 1966 年至 1973 年瑞典药物不良反应委员会报告的材料的分析
DOI：
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发表时间：
1976
影响因子：
2.1
通讯作者：
B. Hallén
中科院分区：
文献类型：
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作者：
L. Böttiger;E. Dalén;B. Hallén
对瑞典药物不良反应委员会提交的 94 份手术和氟烷麻醉后出现肝损伤的患者报告（包括 13 例死亡病例）进行的分析未能揭示除氟烷给药之外的任何其他导致肝损伤的因素。全部材料中的 82% 以及 13 例死亡病例中的 12 例都曾多次接触过。我们的结果表明，反复接触后，肝损伤会变得更加严重；氟烷暴露次数增加后，最大血清胆红素和 SGOT 值会升高。
An analysis of 94 reports to the Swedish Adverse Drug Reaction Committee of patients with liver injury after surgery and halothane anaesthesia (including 13 fatal cases) has not been able to reveal any other factors responsible for the liver injury than the halothane administration. Eighty‐two per cent of the total material and 12 out of 13 fatal cases had had multiple exposures. Our results suggest that the liver injury becomes more severe after repeated exposures; maximum serum bilirubin and SGOT values are higher after an increasing number of halothane exposures.