Development of a remote purification apparatus with disposable evaporator for the routine production of high-quality 64Cu for clinical use
Development of a remote purification apparatus with disposable evaporator for the routine production of high-quality 64Cu for clinical use
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DOI：
10.1016/j.apradiso.2019.01.024
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发表时间：
2019-04-01
影响因子：
1.6
通讯作者：
Zhang, Ming-Rong
中科院分区：
文献类型：
--
作者：
Ohya, Tomoyuki;Minegishi, Katsuyuki;Zhang, Ming-Rong
研制了一种用于临床常规生产Cu-64的新装置。该仪器有许多一次性零件，稳定了产品质量（使产品中杂质金属浓度偏差低），减少了日常生产的准备工作量。我们还开发了一种新的蒸发器，使用近红外加热器一次性使用。我们用新设备进行了生产试验，并对产品质量进行了评价。产物产率为6.3 +/- 0.32 GBq（轰击结束）（N = 4），产品质量（Cu2+, Ni2+, Fe3+, Zn2+, Mn2+）的浓度与通常达到的一样好，可能在十亿分之一的数量级，制备时间从2天缩短到1天。
We developed a new apparatus for the routine production of Cu-64 in clinical use. The apparatus has many disposable parts that stabilize the product quality (such that there is a low deviation of the concentrations of impurity metals in the product) and reduce the work load of preparation for routine production. We also developed a new evaporator using near-infrared heaters for disposable use. We conducted a production test using the new apparatus and evaluated product quality. The product yield was 6.3 +/- 0.32 GBq (end of bombardment) (N = 4), the product quality in terms of the concentrations of impurity metals (Cu2+, Ni2+, Fe3+, Zn2+, Mn2+) was as good as that usually achieved, likely on the order of parts per billion, and the preparation time was reduced from 2 days to 1 day.