Microstructural abnormalities in deep and superficial white matter in youths with mild traumatic brain injury
Microstructural abnormalities in deep and superficial white matter in youths with mild traumatic brain injury
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DOI：
10.1016/j.nicl.2019.102102
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
Sonja Stojanovski;A. Nazeri;Christian Lepage;S. Ameis;A. Voineskos;A. Wheeler
中科院分区：
文献类型：
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作者：
Sonja Stojanovski;A. Nazeri;Christian Lepage;S. Ameis;A. Voineskos;A. Wheeler
背景：脑外伤（TBI）的扩散张量成像（DTI）研究主要集中在脑深部白色纤维（DWM）的微结构特征改变，尽管死后研究表明，受损的轴突经常在灰白质界面处观察到，调解局部连接。目的检查有轻度TBI病史的青少年SWM和DWM的微观结构改变，并检查白色物质改变与方法使用DTIDWM分数各向异性（FA）和SWM FA，将患有轻度TBI（TBI，n=63）的青年与典型发育和精神病理学匹配的对照组（各n=63）进行比较。在基于纤维束的空间统计学之后，通过应用概率纤维束成像衍生的SWM掩模来评估SWM FA，并且用白色物质纤维束掩模捕获DWM FA。使用体素方面的z分数计算来获得每名参与者具有异常高和低FA的体素计数。分析研究DWM和SWM FA TBI和对照组之间的差异，注意力和DWM和SWM FA和SWM的相对易感性之间的关系相比，DWM FA与轻度TBI.ResultsCase-based比较发现更多的体素与低FA和更少的体素与高FA在SWM的青年轻度TBI相比，两个对照组。DWM的等效比较显示了相似的结果模式，然而，在轻度TBI和具有匹配精神病理学的对照组之间，DWM中低FA没有组间差异。较慢的注意力任务的处理速度与体素的数量与低FA在SWM中的青年轻度TBI.ConclusionsWithin一个样本的青年轻度TBI的历史，本研究确定了异常的SWM微结构与处理速度。大多数TBI的DTI研究都集中在长距离DWM纤维束上，经常忽略SWM纤维类型。
BackgroundDiffusion Tensor Imaging (DTI) studies of traumatic brain injury (TBI) have focused on alterations in microstructural features of deep white matter fibers (DWM), though post-mortem studies have demonstrated that injured axons are often observed at the gray-white matter interface where superficial white matter fibers (SWM) mediate local connectivity.ObjectivesTo examine microstructural alterations in SWM and DWM in youths with a history of mild TBI and examine the relationship between white matter alterations and attention.MethodsUsing DTIDWM fractional anisotropy (FA) and SWM FA in youths with mild TBI (TBI, n=63) were compared to typically developing and psychopathology matched control groups (n=63 each). Following tract-based spatial statistics, SWM FA was assessed by applying a probabilistic tractography derived SWM mask, and DWM FA was captured with a white matter fiber tract mask. Voxel-wise z-score calculations were used to derive a count of voxels with abnormally high and low FA for each participant. Analyses examined DWM and SWM FA differences between TBI and control groups, the relationship between attention and DWM and SWM FA and the relative susceptibility of SWM compared to DWM FA to alterations associated with mild TBI.ResultsCase-based comparisons revealed more voxels with low FA and fewer voxels with high FA in SWM in youths with mild TBI compared to both control groups. Equivalent comparisons in DWM revealed a similar pattern of results, however, no group differences for low FA in DWM were found between mild TBI and the control group with matched psychopathology. Slower processing speed on the attention task was correlated with the number of voxels with low FA in SWM in youths with mild TBI.ConclusionsWithin a sample of youths with a history of mild TBI, this study identified abnormalities in SWM microstructure associated with processing speed. The majority of DTI studies of TBI have focused on long-range DWM fiber tracts, often overlooking the SWM fiber type.