Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging
Relationship of Serum Fibroblast Growth Factor 21 with Abnormal Glucose Metabolism and Insulin Resistance: The Baltimore Longitudinal Study of Aging
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DOI：
10.1210/jc.2011-2823
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发表时间：
2012-04-01
影响因子：
5.8
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Sun, Kai;Ferrucci, Luigi
背景：成纤维细胞生长因子21(FGF21)与糖代谢和胰岛素抵抗的关系在社区成年人中尚未得到很好的描述。目的：本研究的目的是探讨FGF21与糖代谢和胰岛素抵抗的关系。设计：2002-2007年进行了一项横断面研究，测量了血清FGF21、空腹血糖(FPG)、糖耐量和胰岛素抵抗。地点：该研究是巴尔的摩老龄化纵向研究，这是一项关于社区居住男性和女性衰老的自然历史队列研究。参与者：700名成年人，平均年龄63.3岁。主要观察指标：空腹血糖、空腹血糖、糖耐量和胰岛素抵抗结果：2 h血糖、胰岛素抵抗稳态模型、全身胰岛素敏感性(松田指数)、血糖曲线下面积(AUC)和胰岛素AUC的中位数分别为225(126,370)pg/ml、77.0、21.4和1.6%，血糖正常、受损和糖尿病的2 h血糖分别为76.7、19.1和4.1%。在调整了潜在混杂因素的多因素有序Logistic回归模型中，对数血清FGF21(皮克数/毫升)与空腹血糖(优势比1.43，95%可信区间1.15，1.77，P=0.001)和2小时血糖(优势比1.39，95%可信区间1.12，1.73，P=0.003)相关。在校正潜在混杂因素的多元线性回归模型中，血清FGF21(微微克/毫升)与胰岛素抵抗的稳态模型、松田指数、血糖AUC和胰岛素AUC(均P<；0.0001)相关。结论：在社区成年人中，血清FGF21浓度升高与糖代谢异常和胰岛素抵抗有关。(临床内分泌代谢酶97：1375-1382,2012)
Context: The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults.Objective: The objective of the study was to examine the relationship of FGF21 with glucose metabolism and insulin resistance.Design: Serum FGF21, fasting plasma glucose (FPG), glucose tolerance, and insulin resistance were measured in a cross-sectional study, 2002-2007.Setting: The study was the Baltimore Longitudinal Study of Aging, a natural history cohort study of aging in community-dwelling men and women.Participants: Seven hundred adults, mean age 63.3 yr, participated in the study.Main Outcome Measures: FPG, 2-h plasma glucose, homeostasis model of insulin resistance, whole-body insulin sensitivity (Matsuda index), glucose area under the curve (AUC), and insulin AUC were measured.Results: Overall, the median (25th and 75th percentiles) FGF21 concentration was 225 (126, 370) pg/ml. The proportion of adults with normal, impaired, and diabetic FPG was 77.0, 21.4, and 1.6%, and those with normal, impaired, and diabetic 2-h plasma glucose was 76.7, 19.1, and 4.1%, respectively. Log serum FGF21 (picograms per milliliter), per 1 SD increase, was associated with an FPG (odds ratio 1.43, 95% confidence interval 1.15, 1.77, P = 0.001) and with 2-h plasma glucose (odds ratio 1.39, 95% confidence interval 1.12, 1.73, P = 0.003), in respective multivariate, ordered logistic regression models, adjusted for potential confounders. Serum FGF21 (picograms per milliliter) was associated with the homeostasis model of insulin resistance, the Matsuda index, glucose AUC, and insulin AUC (all P < 0.0001) in respective multivariable linear regression models adjusted for potential confounders.Conclusions: Higher serum FGF21 concentrations were associated with abnormal glucose metabolism and insulin resistance in community-dwelling adults. (J Clin Endocrinol Metab 97: 1375-1382, 2012)