Effects of complex vertebral malformation on fertility in Swedish holstein cattle.
Effects of complex vertebral malformation on fertility in Swedish holstein cattle.
复制标题
复杂的椎骨畸形对瑞典荷斯坦牛的生育能力的影响。
DOI：
10.1186/1751-0147-45-161
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发表时间：
2004
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
复杂性脊椎畸形（CVM）是荷斯坦牛的一种常染色体隐性遗传病。它导致整个妊娠期的子宫内死亡，导致重复繁殖和非自愿淘汰奶牛，从而造成经济损失。该缺陷于1999年在丹麦首次报道，自2001年2月以来，该缺陷的直接DNA测试已经可用。本研究的目的是调查，如果荷斯坦公牛杂合子的CVM基因降低了繁殖性能，测量不返回率（NRR）和女儿生育指数。包括1995年至1999年出生的所有基因型瑞典荷斯坦公牛。共分析了228头公牛，其中53头公牛，即23%，被确认为CVM携带者。在168天的NRR中，观察到携带者和非携带者之间的NRR相对繁殖值的统计学显著差异（101.1 ± 0.9 vs.103.1 ± 0.6，p < 0.05）。28天NRR无差异，而56天NRR差异接近显著性。父本CVM基因型对子代育性指数无显著影响，可能是由于该指数所包含性状的复杂性。总之，该研究表明，与非携带者相比，CVM缺陷携带者的NRR较差。
Complex vertebral malformation (CVM) is an autosomal recessive inherited defect in the Holstein breed. It causes intra-uterine mortality through the entire gestation period leading to repeat breeding and involuntary culling of cows and thereby economic losses. The defect was first reported in Denmark in 1999 and a direct DNA test for the defect has been available since February 2001. The aim of this study was to investigate if Holstein bulls heterozygous for the CVM gene had reduced reproductive performance, measured as non-return rate (NRR) and in a daughter fertility index. All genotyped Swedish Holstein bulls born between 1995 and 1999 were included. Altogether 228 bulls were analysed, of which 53 bulls, i.e. 23%, were confirmed CVM carriers. A statistically significant difference between carriers and non-carriers in the relative breeding value for NRR was observed for 168 days NRR (101.1 ± 0.9 vs. 103.1 ± 0.6, p < 0.05). There was no difference for 28 days NRR whereas the difference approached significance for 56 days NRR. No significant effect of the paternal CVM genotype on the daughter fertility index was shown probably due to the complexity of traits this index is composed of. In conclusion, the study showed that carriers of the CVM defect have an inferior NRR compared with non-carriers.